Evidence map›Paper›PMID 42126251›Full record

ArticleChemistry & biodiversity2026

Design and Synthesis of Benzofuran-1,4-dihydropyridine Hybrids as Novel Anti-Inflammatory Agents: Theoretical Exploration of a Potential Dual COX-2/TNF-α Mechanism.

Katia Mohand Saidi, Bassam A Najri, Smail Khelili, Kamel Harrouche, Mohamed Zakaria Stiti, Elyes Kelai, Abdelmadjid Guendouzi, Tahir Habila, Arif Kivrak

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katia Mohand SaidiDepartment of Chemistry, Faculty of Exact Sciences and Informatics, University of Mohamed Seddik Ben Yahia-Jijel, Ouled Aissa, Algeria.ORCID https://orcid.org/0009-0006-6894-0551
Bassam A NajriDepartment of Chemistry, Faculty of Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey.
Smail KheliliDepartment of Chemistry, Faculty of Exact Sciences and Informatics, University of Mohamed Seddik Ben Yahia-Jijel, Ouled Aissa, Algeria.ORCID https://orcid.org/0000-0002-7343-0242
Kamel HarroucheDepartment of Chemistry, Faculty of Exact Sciences and Informatics, University of Mohamed Seddik Ben Yahia-Jijel, Ouled Aissa, Algeria.
Mohamed Zakaria StitiDepartment of Chemistry, Faculty of Exact Sciences and Informatics, University of Mohamed Seddik Ben Yahia-Jijel, Ouled Aissa, Algeria.ORCID https://orcid.org/0000-0002-5504-9827
Elyes KelaiCentre De Recherche Scientifique Et Technique En Analyses Physico-Chimiques (CRAPC), Tipaza, Algeria.
Abdelmadjid GuendouziChemistry Laboratory: Synthesis, Properties and Applications (LCSPA), University of Saida, Saida, Algeria.
Tahir HabilaDepartment of Chemistry, Faculty of Exact Sciences and Informatics, University of Mohamed Seddik Ben Yahia-Jijel, Ouled Aissa, Algeria.
Arif KivrakDepartment of Chemistry, Faculty of Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey.

Funding

Algerian Ministry of Higher Education and Scientific Research B00L01UN180120200002Directorate General for Scientific Research and Technological Development
6 · The paper itself

Abstract

This research presents the design, synthesis, and thorough evaluation of a new series of benzofuran-1,4-dihydropyridine hybrids (4a-i) as potential multi-target anti-inflammatory drugs. These compounds were created through an optimized multistep process and examined using a combination of in silico, in vitro, and in vivo methods. Molecular docking revealed a potential dual-target profile, with the leading compounds showing strong predicted binding to both COX-2 and TNF-α. Notably, compound 4i demonstrated the highest affinity for COX-2 (MolDock score = -181.002 kcal/mol), with good selectivity over COX-1 (Δ = -21.35), and also showed one of the strongest affinities for TNF-α (-174.847 kcal/mol). Molecular dynamics simulations confirmed the stability of the 4i-COX-2 complex. This in silico effectiveness was supported by strong in vitro anti-inflammatory activity (eg. 10.09 µg/mL for IC

Indexed as

Anti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalBenzofuransCyclooxygenase 2Cyclooxygenase 2 InhibitorsDihydropyridinesDrug DesignTumor Necrosis Factor-alphaAnimalsCarrageenanCyclooxygenase 1Dose-Response Relationship, DrugEdemaHumansMaleMice1,4-dihydropyridineAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalBenzofuransCarrageenanCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsDihydropyridinesTumor Necrosis Factor-alphaADMETanti‐inflammatory activitybenzofuran‐1,4‐dihydropyridine hybridsgastrointestinal safetymolecular docking and molecular dynamics

Identifiers

PMID42126251
PMCPMC13369426

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.