Evidence map›Paper›PMID 42126242›Full record

ArticlemBio2026

Arm and head domain in highly conserved lipoprotein modification enzyme Lgt determine functional diversity among bacterial pathogens.

Simon Legood, Ana Oliveira Paiva, Najwa Taib, Tristan Ruffiot, Simonetta Gribaldo, Ivo Gomperts Boneca, Nienke Buddelmeijer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simon LegoodInstitut Pasteur, Université Paris Cité, Unité Biologie et Génétique de la Paroi Bactérienne, UMR6047 CNRS, INSERM U1306, Paris, France.
Ana Oliveira PaivaInstitut Pasteur, Université Paris Cité, Unité Biologie et Génétique de la Paroi Bactérienne, UMR6047 CNRS, INSERM U1306, Paris, France.
Najwa TaibInstitut Pasteur, Université Paris Cité, Unité Biologie Évolutive de la Cellule Microbienne, Paris, France.
Tristan RuffiotInstitut Pasteur, Université Paris Cité, Unité Biologie et Génétique de la Paroi Bactérienne, UMR6047 CNRS, INSERM U1306, Paris, France.
Simonetta GribaldoInstitut Pasteur, Université Paris Cité, Unité Biologie Évolutive de la Cellule Microbienne, Paris, France.
Ivo Gomperts BonecaInstitut Pasteur, Université Paris Cité, Unité Biologie et Génétique de la Paroi Bactérienne, UMR6047 CNRS, INSERM U1306, Paris, France.
Nienke BuddelmeijerInstitut Pasteur, Université Paris Cité, Unité Biologie et Génétique de la Paroi Bactérienne, UMR6047 CNRS, INSERM U1306, Paris, France.ORCID 0000-0003-1116-3625

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The post-translational lipoprotein modification pathway is conserved in bacteria, in which prolipoprotein phosphatidylglycerol diacylglyceryl transferase (Lgt) catalyzes the first and committed step. Due to its essentiality for cell viability in Proteobacteria, its membrane localization, and relative accessibility, Lgt is proposed as a promising target for the development of novel antibiotics. To answer the question of the degree of conservation between Lgt homologs of WHO-listed pathogenic species, we performed evolutionary, structural, and functional analyses. Our data show that Lgt is present in all bacteria and absent from archaea. AlphaFold structural models are similar to the X-ray structure of Lgt from

Indexed as

BacteriaLipoproteinsTransferases (Other Substituted Phosphate Groups)Amino Acid SequenceConserved SequenceEscherichia coliModels, MolecularMutagenesis, Site-DirectedProtein DomainsProtein Processing, Post-TranslationalSequence AlignmentTransferasesLipoproteinsphosphatidylglycerol glyceryl transferaseTransferasesTransferases (Other Substituted Phosphate Groups)functional diversityLgtlipoproteinspathogensstructural conservation

Identifiers

PMID42126242
PMCPMC13251419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.