ArticleThe clinical respiratory journal2026
Using Multiple Diagnostic Methods for Occupational Asthma Assessment.
Article in The clinical respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionOccupational asthma (OA) is a significant work-related respiratory disorder requiring accurate diagnostic methods. This study evaluates the sensitivity and specificity of PC20 variability in OA diagnosis and compares it with peak expiratory flow rate (PEFR) monitoring.
methodA retrospective descriptive study was conducted. Fifty-one individuals with suspected OA were assessed. Pulmonary function tests, PEFR monitoring, and methacholine challenge test were performed. PC20 variability was analyzed by comparing values during workplace exposure and after exposure cessation.
resultsA total of 51 suspected occupational asthma (OA) cases were evaluated (mean age: 38.14 ± 8.10 years, 68.6% male). The most common symptom was shortness of breath (mean duration: 19.61 ± 29.23 months), with an average occupational exposure of 7.34 ± 6.82 years, primarily to low molecular weight (LMW) agents. OA was diagnosed in 70.6% (n = 36) of cases, with longer symptom duration and exposure time than nonoccupational asthma. OA cases had longer symptom duration (22.50 ± 32.98 months vs. 12.67 ± 16.08 months in non-OA cases) and slightly longer occupational exposure (7.51 ± 5.94 years vs. 6.92 ± 8.83 years). PC20 (provocative concentration of methacholine causing a 20% fall in FEV
conclusionPC20 variability is a highly sensitive and specific tool for diagnosing OA and may help reduce misdiagnosis associated with PEFR-based assessments. However, in patients where the methacholine challenge test is not feasible, PEFR variability remains a valuable alternative for diagnostic evaluation. Integrating PC20 variability into diagnostic protocols can enhance accuracy and improve patient management.
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