ArticleJMIR research protocols2026
The Prevalence of Mental Health Conditions in Adults and Children With Childhood-Onset Inflammatory Ocular Disease: Protocol for a Systematic Review and Meta-Analysis.
Article in JMIR research protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
backgroundInflammatory ocular diseases (IODs) are frequently associated with multisystem autoimmune conditions and can lead to substantial visual morbidity, including visual impairment and blindness. Emerging evidence suggests that inflammation contributes to the development of depression and other mental health disorders. Individuals with childhood-onset IOD may be at increased risk of poor mental health outcomes and quality of life. However, the prevalence of mental health conditions in this population remains unclear.
objectiveThis study aims to review the evidence regarding the prevalence of mental health conditions among children and adults with childhood-onset IOD.
methodsThis systematic review will follow the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines. Eligible studies will report mental health disorder prevalence and outcomes in individuals with childhood-onset IOD, regardless of age at assessment of outcome. Studies evaluating interventions or focusing primarily on mental health effects secondary to visual impairment or blindness will be excluded. Searches will be conducted in PubMed, the Cochrane Central Register of Controlled Trials, Embase, Ovid, and PsycArticles databases. Gray literature will be identified through Google searches. Two researchers will independently screen titles, abstracts, and full texts; extract data; and assess risk of bias using the risk of bias in nonrandomized studies of exposure tool; disagreements will be resolved by a third reviewer. Data will be synthesized descriptively, with attention to study design, outcome measures, cooccurrence of multisystem disease, and methodological quality.
resultsA preliminary scoping search has been completed to estimate the volume of relevant literature. Full searches began in November 2025. Data collection and extraction is currently in progress. Data extraction, analysis, and synthesis will follow, using a narrative approach to summarize mental health outcomes across studies. The final review is expected to be completed by August 2026.
conclusionsThe findings from this review will help to establish the prevalence of mental health conditions among people with childhood-onset IOD. The results from this review will support recommendations for further research and policies to ensure the best health outcomes for children. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/88888.
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