Evidence map›Paper›PMID 42126109›Full record

ArticleJournal of magnetic resonance imaging : JMRI2026

Quantification of Tricuspid Valve Regurgitation With 2D and 4D-Flow MRI: Comparison of Different Methods in Adult Patients With Ebstein's Anomaly.

Eric Buffle, Mathieu Albertini, Damian Craiem, Victor Waldmann, Francesca Pitocco, Laurence Iserin, Umit Gencer, Elie Mousseaux, Gilles Soulat

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eric BuffleUniversité Paris cité, PARCC, INSERM, Paris, France.ORCID https://orcid.org/0000-0002-2396-5062
Mathieu AlbertiniUniversité Paris cité, PARCC, INSERM, Paris, France.
Damian CraiemInstituto de Medecina Traslacional, Trasplante y Bioingenieria (IMeTTyB), Universidad Favaloro-CONICET, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0003-1065-799X
Victor WaldmannUniversité Paris cité, PARCC, INSERM, Paris, France.ORCID https://orcid.org/0000-0001-8057-1900
Francesca PitoccoRadiology Department, Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.ORCID https://orcid.org/0000-0002-8718-9218
Laurence IserinCardiology Department, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
Umit GencerRadiology Department, Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.ORCID https://orcid.org/0000-0001-5329-7985
Elie MousseauxUniversité Paris cité, PARCC, INSERM, Paris, France.ORCID https://orcid.org/0000-0002-8076-1445
Gilles SoulatUniversité Paris cité, PARCC, INSERM, Paris, France.ORCID https://orcid.org/0000-0003-4165-6113

Funding

Gottfried und Julia Bangerter-Rhyner FoundationSwiss Heart FoundationSwiss National Science Foundation P500PM_214180
6 · The paper itself

Abstract

backgroundEbstein's anomaly (EA) is a congenital heart disorder involving tricuspid valve dysplasia and right heart abnormalities resulting in severe tricuspid regurgitation (TR). Multiple techniques assess regurgitation severity, but their correlation with EA severity markers remains unclear. PURPOSE: To compare MRI techniques for quantifying TR and regurgitant volume (RVol) in adults with EA. STUDY TYPE: Retrospective. SUBJECTS: Thirty-three adult patients with EA (15 males/18 females). FIELD STRENGTH/SEQUENCE: 3T or 1.5-Tesla, 2D-phase contrast (2D-PC gradient echo) and 4D-flow (gradient echo). ASSESSMENT: RVol was measured using three methods: (1) 2D-indirect: subtraction of systolic pulmonary artery (PA) forward flow (2D-PC) from functional right ventricular stroke volume (fRVSV); (2) 4D-indirect: subtraction of PA systolic forward flow from tricuspid diastolic forward flow using 4D-flow; (3) 4D-direct: direct jet measurement with 4D-flow. Correlations were evaluated between RVol and severity markers (left ventricular ejection fraction [LVEF], functional right ventricular end-diastolic volume [fRVEDV], fRV/LV ratio, severity index volume, total right/left volume index, fRVEF). STATISTICAL TESTS: Pearson or Spearman correlation coefficients (p < 0.05) significant.

resultsThe 4D-direct method had the highest correlation with the mean RVol (2D-indirect: r = 0.93, 4D-indirect: r = 0.93; 4D-direct: r = 0.95) and with severity markers: total right/left volume index (0.84, 0.64, 0.87), the fRVEDV (0.66, 0.58, 0.71), fRV/LVratio (0.81, 0.75, 0.87), and severity index volume (0.45, 0.59, 0.66). DATA

conclusion4D-flow enables intrinsic RVol quantification independent of fRV segmentation, with the direct jet method outperforming indirect approaches. LEVEL OF EVIDENCE: 3: TECHNICAL EFFICACY: Stage 2.

Indexed as

Ebstein AnomalyMagnetic Resonance ImagingTricuspid Valve InsufficiencyAdultFemaleHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMaleMiddle AgedReproducibility of ResultsRetrospective StudiesSeverity of Illness IndexStroke VolumeTricuspid ValveYoung Adult4D‐flowEbstein's anomalytricuspid regurgitationvalvular heart disease

Identifiers

PMID42126109
PMCPMC13356333

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.