Evidence map›Paper›PMID 42126091›Full record

ArticleeLife2026

Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability.

Simone Carneiro-Nascimento, Chao Wei, Anna Gutterman, Dan Levy

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Simone Carneiro-NascimentoDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-6141-6080
Chao WeiDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States.
Anna GuttermanDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States.
Dan LevyDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0003-0630-6660

Funding

Response Properties of Meningeal Afferents in Health and MigraineR01NS133625 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DAN LEVY · 2023 to 2026
$2.4M
Cortical-Meningeal Interactions Underlying Migraine HeadacheR01NS115972 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DAN LEVY · 2021 to 2026
$2.3M
Meningeal Nociceptor-Immune Signaling in MigraineR21NS130561 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LEVY, DAN · 2022 to 2022
$492k
NIH HHS R01NS115972NIH HHS R01NS133625NIH HHS R21NS130561NINDS NIH HHS R01 NS115972NINDS NIH HHS R01 NS133625NINDS NIH HHS R21 NS130561
6 · The paper itself

Abstract

The meninges, which envelop and protect the brain, host a dense network of resident macrophages with diverse roles in regulating homeostasis and neuroinflammation. Despite their importance, we have a limited understanding of their behavior in vivo. Many dynamic cellular functions of macrophages involve intracellular Ca

Indexed as

BrainCalciumCalcium SignalingMacrophagesMeningesAnimalsCortical Spreading DepressionIntravital MicroscopyMiceCalciumcalcitonin gene-related peptidecalcium imagingCGRPcortical spreading depolarizationimmunologyinflammationmacrophagesmeningesmigrainemouseneuroscience

Identifiers

PMID42126091
PMCPMC13171100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.