Evidence map›Paper›PMID 42126002›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementia.

Julian Mutz, Lachlan Gilchrist, Oliver Pain, Petroula Proitsi, Cathryn M Lewis

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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Julian MutzSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Lachlan GilchristSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Oliver PainMaurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Petroula ProitsiCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary's University of London, London, UK.
Cathryn M LewisSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Funding

King's College London DRIVE-Health Centre for Doctoral Training and the Perron Institute for Neurological and Translational ScienceKing's Prize FellowshipNational Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre (BRC)Perron Institute for Neurological and Translational ScienceSir Henry Wellcome Postdoctoral Fellowship 222811/Z/21/ZWellcome Trust
6 · The paper itself

Abstract

introductionIdentifying individuals at risk of dementia is essential for prevention and targeted disease-modifying strategies. We investigated whether mid-life metabolomic ageing is associated with incident dementia and its age of onset and assessed joint associations and interactions with APOE genotype and dementia polygenic scores.

methodsIn the UK Biobank, plasma metabolites were quantified at baseline. Metabolomic age (MileAge) delta reflects the difference between metabolite-predicted and chronological age. Dementia was identified via health records.

resultsAmongst 223,496 participants, 3976 developed dementia. A higher MileAge delta was associated with higher hazards of all-cause, unspecified and vascular dementia (HR = 1.61, 95% CI 1.28-2.02, p = 0.001) and earlier onset. Key metabolites were lipids, lipoproteins and amino acids. MileAge delta and genetic risk were jointly associated with dementia. Individuals with a high MileAge delta and two APOE ε4 alleles had a 10.30-fold higher all-cause dementia risk (95% CI 7.95-13.34, p < 0.001). DISCUSSION: Metabolomic ageing and genetic risk likely represent independent biological pathways contributing to dementia risk.

Indexed as

AgingDementiaDementia, VascularMetabolomicsApolipoproteins EFemaleGenetic Risk ScoreHumansIncidenceMaleUK BiobankUnited KingdomApolipoproteins Eageingbiological agedementiametabolomic agemetabolomics

Identifiers

PMID42126002
PMCPMC13169133

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.