Evidence map›Paper›PMID 42125896›Full record

ArticleBone & joint research2026

Sex-specific hormonal rescue of bone growth in PAPPA2-deficient mice : a role for cannabinoid receptors and STAT3.

María Del Mar Fernández-Arjona, Antonio J López-Gambero, Leticia Rubio, Miguel Rodríguez-Pozo, Patricia Rivera, Marialuisa de Ceglia, Antonio Vargas, Fernando Rodríguez de Fonseca, Julie A Chowen, Jesús Argente and 1 more

Abstract read
In one paragraph

Article in Bone & joint research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

María Del Mar Fernández-ArjonaInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.ORCID 0000-0001-5673-9806
Antonio J López-GamberoInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.ORCID 0000-0001-7716-9056
Leticia RubioInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.ORCID 0000-0002-8233-624X
Miguel Rodríguez-PozoInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.ORCID 0009-0007-5276-6082
Patricia RiveraInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.ORCID 0000-0002-0478-6667
Marialuisa de CegliaInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.ORCID 0000-0003-4256-7702
Antonio VargasInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.ORCID 0009-0003-8131-115X
Fernando Rodríguez de FonsecaInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.ORCID 0000-0002-4516-5795
Julie A ChowenDepartments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.ORCID 0000-0002-4770-2291
Jesús ArgenteDepartments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.ORCID 0000-0001-5826-0276
Juan SuárezInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.ORCID 0000-0001-5254-9802

Funding

Instituto de Salud Carlos IIIMinisterio de Economía, Industria y CompetitividadNetwork Center for Biomedical Research on Obesity and NutritionSpanish Ministry of Science and Innovation
6 · The paper itself

Abstract

Aims: Recombinant human (rh) insulin-like growth factor-1 (IGF1) treatment has been shown to restore growth velocity and height in children harbouring pregnancy-associated plasma protein-A2 ( Methods: Results: At the onset of puberty, hormone-treated knockout Conclusion: These findings support rhPAPP-A2 as a promising therapeutic candidate for mitigating postnatal bone growth retardation by increasing bone formation and reducing resorption through cannabinoid receptor modulation in a female-specific manner.

Identifiers

PMID42125896
PMCPMC13169458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.