ArticleBone & joint research2026
Sex-specific hormonal rescue of bone growth in PAPPA2-deficient mice : a role for cannabinoid receptors and STAT3.
Article in Bone & joint research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
Funding
Abstract
Aims: Recombinant human (rh) insulin-like growth factor-1 (IGF1) treatment has been shown to restore growth velocity and height in children harbouring pregnancy-associated plasma protein-A2 ( Methods: Results: At the onset of puberty, hormone-treated knockout Conclusion: These findings support rhPAPP-A2 as a promising therapeutic candidate for mitigating postnatal bone growth retardation by increasing bone formation and reducing resorption through cannabinoid receptor modulation in a female-specific manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.