ReviewBirth defects research2026
How Epigenetics Bridges Genes and Environment: A Multiomics Evidence Chain in Congenital Diaphragmatic Hernia.
Review in Birth defects research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
Abstract
BACKGROUND/
objectivesCongenital diaphragmatic hernia (CDH) is a severe developmental anomaly with high etiological heterogeneity. Although numerous susceptibility genes have been identified, genetic factors alone fail to explain the full disease risk. Epidemiological data highlight the contribution of environmental exposures. Epigenetic regulation provides a crucial link bridging genetic predisposition and environmental influence. This review aims to summarize recent multiomics evidence elucidating how epigenetic mechanisms mediate gene-environment interactions in CDH.
methodsThis narrative review summarizes studies published over the past decade on epigenetic mechanisms in congenital diaphragmatic hernia (CDH), including DNA methylation, histone modifications, noncoding RNAs, and integrative genomic and transcriptomic analyses in human samples, animal models, and iPSC-derived organoids. Relevant literature was identified through targeted searches of the biomedical literature and screening of reference lists from key articles. Relevant studies were considered according to their relevance to epigenetic regulation, gene-environment interactions, and translational implications in CDH.
resultsAberrant DNA methylation, histone acetylation imbalance, and dysregulated miRNAs converge on key developmental pathways, including retinoic acid, TGF-β, and NF-κB signaling. Experimental evidence shows that miR-200b supplementation or pharmacological restoration of histone acetylation can partially rescue pulmonary hypoplasia in nitrofen-induced CDH models. iPSC and organoid systems further demonstrate synergistic effects between genetic susceptibility and mechanical stress, supporting epigenetic regulation as a mechanistic bridge.
conclusionsEpigenetic mechanisms serve as core mediators linking genetic and environmental factors in CDH pathogenesis. Future directions include large-scale EWAS/WGBS and multiomics integration, establishment of standardized epigenetic databases, and ethically guided development of prenatal epigenetic diagnostics and targeted interventions.
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