ArticleHaemophilia : the official journal of the World Federation of Hemophilia
Health-Related Quality of Life Among Female Carriers of Haemophilia and Non-Carriers in a Colombian Population.
Article in Haemophilia : the official journal of the World Federation of Hemophilia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionWomen with haemophilia can present manifestations and experience undiagnosed symptoms, which negatively affect their health-related quality of life (HRQoL).
objectiveTo evaluate the HRQoL in obligate carriers of haemophilia (OCH) versus women non-carriers of haemophilia (WNCH) in a Colombian population.
methodsObservational, cross-sectional study of women over 18 years. OCH were defined as daughters of a father with haemophilia, mothers of two or more sons with haemophilia, or mothers of one son with haemophilia and another affected relative. OCH were matched 1:1 with WNCH according to socioeconomic stratum and age. Women with other haematological pathologies, use of anticoagulants or antiplatelets, pregnancy or cognitive impairment were excluded. The Bleeding Assessment Tool (ISTH-BAT) was used to evaluate bleeding symptoms, and the SF-36 questionnaire was used to measure HRQoL.
resultsA total of 104 women were included (52 OCH and 52 WNCH), with a median age of 49 years (IQR 40.5-48.5). WNCH had higher educational levels and a lower proportion of homemakers (23.8% vs. 46.15%; p = 0.015). A total of 38.46% had abnormal bleeding (ISTH-BAT ≥ 6), which was more frequent in OCH (75% vs. 1.92%; p < 0.01), with menorrhagia being the most prevalent manifestation (90.38% vs. 44.23%; p < 0.01). OCH reported lower scores in all of the SF-36 domains, with greater involvement in physical role (65.38%), while the WNCH reported a lower score in mental health (17.31%).
conclusionCompared with WNCH, OCH have a significantly more compromised HRQoL, which highlights the need for specific interventions to improve their physical and psychosocial well-being.
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