Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Chinyere O Ibikunle *Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).
Enrique J Garcia *Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).ORCID 0000-0002-4779-5766
Chenyi XueDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).ORCID 0000-0002-8829-7659
Eunyoung KimDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).ORCID 0000-0002-9749-9930
Hanying YanDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia (H.Y., M.L.).ORCID 0000-0002-9227-1742
Johana CoronelDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).ORCID 0000-0002-9257-0849
Lucie Y ZhuDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).ORCID 0000-0002-1048-5377
Jian CuiDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).
Allen ChungDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).ORCID 0000-0002-2494-9179
Lauren E FriesDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).ORCID 0000-0003-3148-440X
Nadja SachsDepartment of Vascular and Endovascular Surgery, Technical University Munich (TUM) University Hospital Klinikum, TUM, Germany (N.S.).ORCID 0000-0001-8031-017X
Robert C BauerDivision of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).ORCID 0000-0001-9752-9645
Lars MaegdefesselInstitute of Molecular Vascular Medicine, TUM Klinikum, TUM, Germany (L.M.).ORCID 0000-0001-5228-2634
Mingyao LiDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia (H.Y., M.L.).ORCID 0000-0003-2422-9494
Alan R TallDivision of Molecular Medicine, Department of Medicine (A.R.T.), Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-7708-2417
Alexander C Bashore *Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).ORCID 0000-0002-1380-9242
Muredach P Reilly *Division of Cardiology, Department of Medicine, Vagelos College of Physicians and Surgeons, New York, NY (C.O.I., E.J.G., C.X., E.K., J. Coronel, L.Y.Z., J. Cui, A.C., L.E.F., R.C.B., A.C.B., M.P.R.).ORCID 0000-0002-3035-9386
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCHT32HL007343 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENRY N GINSBERG, Muredach P Reilly · 1985 to 2026
$12.7M
Mouse and Human Atherosclerotic TissueP01HL172741 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Hanrui Zhang · 2024 to 2026
$9.5M
Cholesterol efflux, CHIP and inflammasome activationR01HL107653 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2011 to 2026
$7.7M
Elucidation of Tissue-Specific Transcriptomic Profiles in Cardiometabolic DiseaseR01HL113147 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LI, MINGYAO, REILLY, MUREDACH P · 2012 to 2022
$6.8M
Clonal hematopoiesis, inflammasomes and atherosclerosisR01HL155431 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2021 to 2026
$3.7M
Smooth muscle cell-derived cell fates and cellular interactions in atherosclerotic plaque stability in disease progression and regression.R01HL166916 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Muredach P Reilly · 2023 to 2026
$2.8M
Computational and functional strategies to decipher lncRNAs in human atherosclerosisR01HL150359 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LI, MINGYAO, REILLY, MUREDACH P · 2020 to 2023
$2.7M
Identification of smooth muscle cell genes causal in atherosclerotic plaque stability and cardiovascular disease riskR01HL169766 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Muredach P Reilly, Danish Saleheen · 2023 to 2026
$2.6M
Molecular Mechanisms of TRIB1 Regulation of Hepatic MetabolismR01DK134026 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert Clayton Bauer · 2023 to 2026
$2.5M
Integration of spatial transcriptomics, genetics, and histomorphology for causal inference in atherosclerotic cardiovascular diseaseR01HL171595 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Muredach P Reilly · 2024 to 2026
backgroundVascular smooth muscle cells (VSMCs) play a central role in atherosclerosis by undergoing phenotypic modulation from a quiescent, contractile state to a range of synthetic phenotypes, including fibroblast-like, macrophage-like, and lipid-laden foam cell-like states. However, a comprehensive multimodal characterization and understanding of the transcriptional programs driving these transitions remain incomplete.
methodsTo comprehensively define the phenotypic diversity of VSMCs during atherosclerosis progression, we performed in-depth profiling using cellular indexing of transcriptomes and epitopes by sequencing and bulk RNA sequencing in a VSMC-lineage-tracing atherosclerotic mouse model. Insights from these data sets guided the design of targeted in vitro experiments to investigate candidate regulatory mechanisms.
resultsSingle-cell multiomics revealed extensive cellular heterogeneity within atherosclerotic plaques, including a rare population of VSMC-derived macrophage-like cells, whose presence was confirmed by histological analysis. These studies also identified a large population of VSMC-derived foam cells that exhibited activation of gene programs associated with lipid metabolism, proliferation, and tumor-like features. The transcription factor BHLHE40 (basic helix-loop-helix family member e40) emerged as a candidate regulator of this phenotypic transition, with elevated expression and activity in VSMC-derived foam cells during disease progression and expression in modulated VSMC in human carotid atherosclerosis. Functional knockdown of
conclusionsThese findings advance our understanding of VSMC phenotypic modulation in atherosclerosis and implicate BHLHE40 as a candidate transcriptional regulator of this process. Elucidating mechanisms governing VSMC plasticity may offer new therapeutic opportunities to reduce cardiovascular risk by targeting disease-driving cellular transitions.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Atherosclerosis Profiling Reveals BHLHE40 as a Candidate Modulator of VSMC. · full record | OpenQuestion