Trajectory of serial neutrophil-to-lymphocyte ratio predicts neurological outcome after out-of-hospital cardiac arrest.

Kyungman Cha, Sang Hoon Oh, Jee Yong Lim

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Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors.

Kyungman ChaDepartment of Emergency Medicine, Suwon St. Vincent Hospital, College of Medicine, The Catholic University of Korea, 93 Jungbu-daero, Paldal-gu, Suwon-si, Gyeonggi-do 16247, the Republic of Korea.

Sang Hoon OhDepartment of Emergency Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, the Republic of Korea.

Jee Yong LimInternational Healthcare Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, the Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To evaluate whether serial neutrophil-to-lymphocyte ratio (NLR) trajectory patterns and individual time-point NLR values predict neurological outcome after out-of-hospital cardiac arrest (OHCA). Methods: This retrospective study analyzed 414 comatose OHCA survivors treated with targeted temperature management at a tertiary center (2009-2024). NLR was calculated at 0, 24, 48, and 72 h after return of spontaneous circulation. The primary outcome was 6-month Cerebral Performance Category dichotomized as good (1-2) or poor (3-5). Patients with complete serial data ( Results: Among 414 patients, 131 (31.6%) achieved good outcomes. NLR did not differ between groups at 0 or 24 h but diverged at 72 h (median 6.0 vs 13.9; Conclusions: Failure of NLR to resolve by 72 h was associated with poor neurological outcome in this cohort. As NLR is derived from routine blood counts at no additional cost, it may serve as an accessible complement to specialized prognostic biomarkers, particularly in settings where neuron-specific enolase is unavailable. These findings require prospective multicenter validation.

Indexed as

Cardiac arrestInflammatory biomarkerLymphocyte recoveryNeuroprognosticationNeutrophil-to-lymphocyte ratioTargeted temperature management

Identifiers

PMID42125737

DOI10.1016/j.resplu.2026.101337

PMCPMC13158605

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