ArticleInternational journal of general medicine2026
Apolipoprotein B/A1 Ratio for Predicting Major Adverse Cardiovascular Events in Coronary Artery Disease: Development and Validation of a Nomogram.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The apolipoprotein B to apolipoprotein A1 (ApoB/A1) ratio has emerged as a superior lipid marker for cardiovascular risk assessment. This study aimed to develop and validate a nomogram incorporating the ApoB/A1 ratio for predicting major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Methods: This retrospective cohort study included 2459 patients undergoing PCI, randomly allocated to training (n=1721) and validation (n=738) cohorts. LASSO regression and multivariable Cox regression were used for variable selection and model development. Model performance was evaluated using C-index, calibration curves, and decision curve analysis. Results: During a median follow-up of 33.8 months, MACE occurred in 187 patients (7.6%). The ApoB/A1 ratio was independently associated with MACE (HR 1.12 per 0.1 increase, 95% CI 1.06-1.19, Conclusion: The ApoB/A1 ratio may be an independent predictor of MACE in CAD patients after PCI. The developed nomogram showed promising performance for risk prediction and stratification in this retrospective cohort. External validation in prospective studies is warranted before clinical implementation.
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