ArticleFrontiers in oncology2026
Association of NDRG4 gene methylation in peripheral blood leukocytes with gastric cancer risk, chemotherapy efficacy and prognosis.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To analyze the functions of NDRG family genes in gastric cancer (GC) utilizing bioinformatics. Furthermore, the association between the methylation of NDRG4 gene in peripheral blood leukocytes (PBLs) and GC risk, chemotherapy efficacy, and prognosis was analyzed. Methods: Using TCGA and GEO databases, the study analyzed the expression, immune related signatures, methylation patterns and prognostic of NDRG family genes. Two-phase case-control study (310 GC patients and 300 controls) was conducted to investigate the association between the methylation of NDRG4 gene and GC risk. In addition, this study explored the association between methylation of NDRG4 gene and the therapeutic effect and prognosis of GC. The expression level of NDRG4 gene was compared between the hypermethylation and hypomethylation groups. The single nucleotide polymorphism (SNP) rs7202037 genotypes of 280 GC patients were detected, and the methylation level differences among rs7202037 genotypes were compared. Results: Bioinformatics analysis showed that the expression of NDRG family genes was related to immunity and methylation ( Conclusions: The methylation of NDRG4 gene in PBLs was associated with GC risk, chemotherapy efficacy and prognosis. The rs7202037 variation could affect the methylation levels of NDRG4 gene. These findings provided new directions for exploring the pathogenesis of GC and screening non-invasive marker.
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