Evidence map›Paper›PMID 42125645›Full record

ArticleInternational journal of microbiology2026

Determinants of Antimicrobial Resistance in

Mihails Dolgusevs, Nityanand Jain, Oksana Savicka, Reinis Vangravs, Jevgenijs Bodrenko, Liene Ostele-Cešķe, Gustavs Rindžs, Dace Zemite, Aigars Reinis, Baiba Rozentale

Abstract read
In one paragraph

Article in International journal of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Determinants of Antimicrobial Resistance inInternational journal of microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mihails DolgusevsDepartment of Doctoral Studies, Riga Stradins University, 16 Dzirciema Street, Riga, LV-1007, Latvia, rsu.lv.ORCID https://orcid.org/0000-0003-4977-3867
Nityanand JainFaculty of Medicine, Riga Stradins University, 16 Dzirciema Street, Riga, LV-1007, Latvia, rsu.lv.ORCID https://orcid.org/0000-0002-7918-7909
Oksana SavickaDepartment of Infectology, Riga Stradins University, 16 Dzirciema Street, Riga, LV-1007, Latvia, rsu.lv.ORCID https://orcid.org/0000-0003-0047-3644
Reinis VangravsLaboratory "Latvian Centre of Infectious Diseases", National Microbiology Reference Laboratory, Riga, LV-1006, Latvia.ORCID https://orcid.org/0000-0001-9067-8912
Jevgenijs BodrenkoLaboratory "Latvian Centre of Infectious Diseases", National Microbiology Reference Laboratory, Riga, LV-1006, Latvia.ORCID https://orcid.org/0009-0007-7085-7762
Liene Ostele-CešķeIntensive Care Unit, Liepaja Regional Hospital, 25 Slimnicas Street, Liepaja, LV-3414, Latvia.ORCID https://orcid.org/0009-0008-6293-0525
Gustavs RindžsIntensive Care Unit, Liepaja Regional Hospital, 25 Slimnicas Street, Liepaja, LV-3414, Latvia.ORCID https://orcid.org/0009-0002-1097-1938
Dace ZemiteLaboratory "Centrala Laboratorija" Ltd., 25 Slimnicas Street, Liepaja, LV-3414, Latvia.ORCID https://orcid.org/0000-0001-7370-0495
Aigars ReinisJoint Microbiology Laboratory, Pauls Stradinš Clinical University Hospital, 13 Pilsonu Street, Riga, LV-1002, Latvia.ORCID https://orcid.org/0000-0002-3671-1213
Baiba RozentaleDepartment of Public Health and Epidemiology, Riga Stradins University, 16 Dzirciema Street, Riga, LV-1007, Latvia, rsu.lv.ORCID https://orcid.org/0000-0002-7293-3307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: We conducted an integrated phenotypic-genotypic analysis of Results: We analysed 52 clinical isolates from 45 ICU patients. Multidrug resistance was nearly universal (98%), with complete resistance to carbapenems and fluoroquinolones and > 95% resistance to aminoglycosides and trimethoprim-sulfamethoxazole. Colistin activity was largely preserved, with resistance detected in only one isolate, despite widespread polymyxin resistance-associated mutations. Genotypic findings were mostly in line with the phenotypic results. All isolates belonged to the ST2 lineage, highlighting clonal homogeneity. No plasmid replicons were detected, suggesting chromosomal elements as the primary resistance drivers. Conclusions: Our first integrated dataset in an ICU setting from the Baltic region demonstrates alarming resistance levels and clonal dominance of ST2. Our findings highlight the importance of combining WGS with susceptibility testing for accurate resistance assessment.

Indexed as

Acinetobacter baumanniigenotypeintensive care unitsphenotyperesistance

Identifiers

PMID42125645
PMCPMC13159539

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.