ArticleExperimental and therapeutic medicine2026
Risk factors for anastomotic leakage after anterior resection of rectal cancer with preservation of the left colic artery.
Article in Experimental and therapeutic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Anastomotic leakage (AL) is a frequent and severe complication after anterior resection for rectal cancer. Most previous studies compared AL incidence between high and low ligation; however, the present study evaluated risk factors for AL in patients undergoing low ligation with preservation of the left colic artery, which has been associated with improved overall outcomes. Clinical data of patients with rectal cancer treated in the Second Department of General Surgery (Gastrointestinal Surgery) of The First Affiliated Hospital of Guangdong Pharmaceutical University (Guangzhou, China) between 2015 and 2024 were retrospectively reviewed, and patients meeting the inclusion and exclusion criteria were enrolled. Demographic characteristics and perioperative variables were collected. Differences between the AL group and the non-AL group were assessed using univariate analysis, and independent associations were identified using multivariate analysis to produce odds ratios (ORs). A total of 137 patients were included. Intergroup comparative tests showed significant differences in alcohol consumption, distance from the tumor to the anal verge and distance from the anastomosis to the anal verge between the AL group and the non-AL group (P<0.05). Multivariate analysis identified alcohol consumption (OR=9.845; P=0.0068) and distance from the tumor to the anal verge (OR=0.485; P=0.0368) as independent factors associated with AL. In conclusion, alcohol consumption and distance from the tumor to the anal verge are independent risk factors for AL after anterior resection with preservation of the left colic artery. The risk of AL is 9.845-fold higher in patients with alcohol consumption. For each 1 cm decrease in distance from the tumor to the anal verge, the risk of AL increases by 2.060-fold.
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