Evidence map›Paper›PMID 42125478›Full record

ArticleERJ open research2026

Preschool wheeze endotypes and their association with asthma attacks and inhaled corticosteroid response.

Andreas Perikleous, Sarah-Jane Bowen, Chris Griffiths, Ian Pavord, Mark Rosenthal, Louise Fleming, Andrew Bush

Abstract read
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In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andreas PerikleousNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-5017-8347
Sarah-Jane BowenJohn Radcliffe Children's Hospital, Oxford, UK.ORCID https://orcid.org/0009-0003-5863-6423
Chris GriffithsCentre for Applied Respiratory Research Innovation and Impact (CARRii), Nuffield Department of Primary Health Care Sciences, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-7935-8694
Ian PavordNuffield Department of Medicine, University of Oxford, Oxford, UK.
Mark RosenthalRoyal Brompton Hospital, London, UK.
Louise FlemingNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0002-7268-7433
Andrew BushNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-6756-9822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Eosinophilic airway inflammation predicts asthma attacks and inhaled corticosteroid (ICS) response in adults; similar mechanisms may apply to preschool wheeze. This study assessed whether blood eosinophil count (BEC) alone or combined with allergic sensitisation and fractional exhaled nitric oxide ( Methods: 95 preschool children (12-59 months old) with clinician-confirmed wheeze were recruited from primary and secondary care. At baseline, finger-prick BEC, skin-prick testing for allergic sensitisation and offline Results: Children with BEC ≥300 cells·μL Conclusion: Elevated BEC may identify preschool children at increased wheeze attack odds, particularly when combined with

Identifiers

PMID42125478
PMCPMC13158983

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.