ArticleInfection and drug resistance2026
Clinical Characteristics and Whole-Genome Sequencing Analysis of Carbapenem- and Colistin-Resistant Hypervirulent
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colistin‑resistant hypervirulent carbapenem‑resistant Methods: From 2021 to 2024, 326 non-duplicate hv-CRKP isolates were collected from patients with confirmed clinical infections at a tertiary hospital in China. Antimicrobial susceptibility was determined by broth microdilution. Clinical data were retrospectively analyzed, and logistic regression identified risk factors for ColR‑hv‑CRKP infection. Whole‑genome sequencing was performed to characterize molecular characteristics and colistin resistance-associated mutations. Results: Ninety‑two isolates (92/326, 28.22%) were colistin‑resistant by broth microdilutionby. Patients with ColR‑hv‑CRKP infection were more likely to have a history of ICU admission, prolonged hospitalization, and invasive procedures, were more likely to have isolates recovered from sputum specimens, and had more frequent prior exposure to colistin (all P < 0.05). Multivariable analysis identified prior colistin administration (OR = 4.58, 95% CI 2.41-8.69) and sputum specimen source (OR = 2.44, 95% CI 1.35-4.42) as independent risk factors for ColR-hv-CRKP infection. Whole‑genome sequencing revealed that most ColR‑hv‑CRKP isolates belonged to ST11 (90/92, 97.83%), mainly KL64 (52/92, 56.52%) or KL25 (36/92, 39.13%). Carbapenem resistance was primarily mediated by Conclusion: Colistin resistance in hv‑CRKP was mainly associated with
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.