Evidence map›Paper›PMID 42125437›Full record

ArticleJournal of the anus, rectum and colon2026

Molecular Analysis of Biliary Tract Neoplasms Associated with Familial Adenomatous Polyposis.

Takehiro Shiraishi, Hideyuki Ishida, Takatoshi Matsuyama, Noriyasu Chika, Yoshiko Mori, Noriko Tanabe, Hidetaka Eguchi, Yasushi Okazaki, Toshiro Ogura, Ibuki Fujinuma and 2 more

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In one paragraph

Article in Journal of the anus, rectum and colon, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Takehiro ShiraishiDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
Hideyuki IshidaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
Takatoshi MatsuyamaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
Noriyasu ChikaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
Yoshiko MoriDepartment of Clinical Genetics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
Noriko TanabeDepartment of Clinical Genetics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
Hidetaka EguchiDiagnostics and Therapeutics of Intractable Diseases and Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Yasushi OkazakiDiagnostics and Therapeutics of Intractable Diseases and Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Toshiro OguraDepartment of Gastroenterological Surgery, Saitama Cancer Center, Ina, Kita-adachi gun, Saitama, Japan.
Ibuki FujinumaDepartment of Gastroenterological Surgery, Saitama Cancer Center, Ina, Kita-adachi gun, Saitama, Japan.
Tatsuro YamaguchiDepartment of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Tetsuji TakayamaDepartment of Gastroenterology and Oncology, Tokushima University Graduate School of Medical Science, Tokushima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Familial adenomatous polyposis (FAP) is an inherited disorder characterized by multiple colorectal polyposis and is frequently associated with a variety of extracolonic lesions. However, neoplastic lesions of the biliary tract system, excluding those of the ampulla of Vater, are extremely rare in FAP, and the impact of Methods: A total of 115 genetically confirmed FAP cases treated at our department between 1997 and 2024 were investigated regarding development of BTNs. Results: Of 115 FAP cases, three developed BTNs. Case 1 was a 69-year-old female who underwent subtotal stomach-preserving pancreaticoduodenectomy for duodenal and middle bile duct carcinoma. Case 2 was a 67-year-old female who underwent pancreaticoduodenectomy for gastric, duodenal, and upper bile duct carcinoma. Case 3 was a 47-year-old male who underwent pancreas-sparing total duodenectomy with cholecystectomy for Spigelman Stage IV duodenal polyposis and gallbladder polyposis. In addition to germline pathogenic variants, somatic pathogenic variants of Conclusions: These findings suggest that the

Indexed as

APC genebiliary tract neoplasmfamilial adenomatous polyposisgermline variant

Identifiers

PMID42125437
PMCPMC13160581

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.