ArticleClinical ophthalmology (Auckland, N.Z.)2026
Corneal Biomechanics Before and After Descemet Membrane Endothelial Keratoplasty in Patients with Fuchs Endothelial Corneal Dystrophy.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Descemet Membrane Endothelial Keratoplasty (DMEK) is a surgical intervention for restoring endothelial function in Fuchs endothelial corneal dystrophy (FECD). However, changes in corneal biomechanical properties assessed using dynamic Scheimpflug analyzer (DSA) remain limited. This study aimed to assess alterations in corneal biomechanical parameters before and after surgery in patients with FECD using DSA. Patients and Methods: This prospective study included 24 FECD patients. Demographic data, visual acuity, central corneal thickness (CCT), endothelial cell count, intraocular pressure (IOP), stress strain index (SSI) and others DSA parameters were evaluated. Measurements were obtained preoperatively and at 1, 3, and 6 months after surgery. Repeated measures analysis of variance and pairwise correlations were used to assess differences and associations. Results: Significant postoperative alterations were observed in multiple corneal biomechanical parameters. CCT, ARTh, A1 length, A1 DefA and SPA showed significant reductions over time. Conversely, the DefA max, maximum inverse radius, DA ratio, integrated radius and CBI significantly increased during follow-up. While, SSI remained stable at all time points. These findings demonstrate a biomechanical transformation following DMEK from 1 to 6 months postoperatively, reflecting the transition from a swollen, thickened cornea to a thinner, clearer cornea in the postoperative state. Conclusion: DMEK resulted in reduced corneal thickness and significant changes in several corneal biomechanical parameters. However, the stability of SSI, which is independent of CCT and bIOP, suggests that intrinsic corneal stiffness remains unchanged despite postoperative remodeling. The observed biomechanical alterations may provide useful markers for monitoring corneal recovery following DMEK.
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