Evidence map›Paper›PMID 42125330›Full record

ArticleEuropean heart journal open2025

Soluble urokinase plasminogen activator receptor for risk stratification from undifferentiated acute chest pain through to convalescence after acute coronary syndromes.

Taylor Keys, Charlotte Greer, Philip D Adamson, John W Pickering, Anna P Pilbrow, Christopher Frampton, Salim Hayek, Richard W Troughton, Robert N Doughty, A Mark Richards and 2 more

Abstract read
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Taylor KeysDepartment of Medicine, Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand.
Charlotte GreerDepartment of Medicine, Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand.ORCID https://orcid.org/0000-0001-5755-5355
Philip D AdamsonDepartment of Medicine, Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand.ORCID https://orcid.org/0000-0002-6177-956X
John W PickeringDepartment of Medicine, Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand.
Anna P PilbrowDepartment of Medicine, Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand.ORCID https://orcid.org/0000-0003-1949-9449
Christopher FramptonDepartment of Medicine, Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand.
Salim HayekDepartment of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA.
Richard W TroughtonDepartment of Medicine, Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand.
Robert N DoughtyGreenlane Cardiovascular Service, Te Toka Tumai Auckland Hospital, 2 Park Road, Grafton, Auckland 1023, New Zealand.
A Mark RichardsDepartment of Medicine, Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand.
Christopher J PembertonDepartment of Medicine, Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand.
Janice Chew-HarrisDepartment of Medicine, Christchurch Heart Institute, University of Otago, 2 Riccarton Avenue, Christchurch 8011, New Zealand.ORCID https://orcid.org/0009-0005-0946-9045

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: The performance of plasma soluble urokinase plasminogen activator receptor (suPAR) for prediction of heart failure (HF) readmission or death within 5 years was assessed in patients incurring (i) initially undifferentiated chest pain and (ii) immediately after diagnosed with acute coronary syndromes (ACS), and (iii) in recovery after ACS. Methods and results: Soluble urokinase plasminogen activator receptor concentrations were measured at admission for acute chest pain patients ( Conclusion: Plasma suPAR independently predicted risk of readmissions with HF and death, independent of key clinical indicators and cardiac markers at all points of the patient journey from acute chest pain presentation through to post-ACS convalescence. Its use in acute chest pain and ACS may augment risk stratification strategies.

Indexed as

ACSCardiac biomarkersConcentrationsRisksuPAR

Identifiers

PMID42125330
PMCPMC13158661

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.