ArticleFrontiers in nutrition2026
The impact of psychosocial factors on secondary hyperparathyroidism and vitamin D deficiency in adults with congenital heart disease-the CHD-HYPER study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Secondary hyperparathyroidism (sHPT) and vitamin D deficiency are common comorbidities in adults with congenital heart disease (ACHD), but the relationship with lifestyle factors, and psychosocial health remains poorly understood. Methods: This single-center cross-sectional study included 662 ACHD patients (mean age: 39.3 years; 47% female) and analyzed their clinical, psychosocial, and lifestyle data, including laboratory parameters, quality of life (QoL), and mental health metrics. Predictors of sHPT and vitamin D deficiency were evaluated using multivariate regression models. Findings: sHPT was observed in 13% and vitamin D deficiency in 43.4% of patients. In the multivariate analysis, infrequent alcohol consumption ( Conclusion: This study highlights the multifactorial etiology of sHPT and vitamin D deficiency in ACHD, underscoring the roles of disease severity, lifestyle, and psychosocial factors. sHPT appears to be closely associated with advanced cardiac disease and heart failure and may serve as a marker of increased disease burden. Accordingly, assessment of sHPT may contribute to a more comprehensive risk stratification in ACHD. Further studies are needed to determine whether targeted interventions improve clinical outcomes.
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