Thermal-enhanced self-heating microneedle patch for sustained progesterone delivery and improved pregnancy maintenance.

Huiling Shen, Guifang Pan, Xingxing Li, Yichao Guo, Wenjian Zhang, Chenchen Wei, Hao Yuan, Jundong Shao

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huiling ShenSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510182, China.

Guifang PanSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510182, China.

Xingxing LiSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510182, China.

Yichao GuoSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510182, China.

Wenjian ZhangSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510182, China.

Chenchen WeiSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510182, China.

Hao YuanSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510182, China.

Jundong ShaoSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510182, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progesterone (PG) deficiency is a leading cause of impaired pregnancy maintenance, while current therapies such as frequent intramuscular injections suffer from poor compliance, inconvenience, and clinical risks. To address these issues, we report a self-heating microneedle (MN) patch designed for comfortable, sustained, and efficient thermally enhanced transdermal delivery of PG. The integrated system incorporates PG-loaded MNs, a 3D-printed backing layer with trigger mechanism, and a quicklime/activated charcoal (CaO + C) exothermic mixture that enables controllable and efficient self-heating effects (>60 °C).

Indexed as

Microneedle patchPregnancy maintenanceProgesteroneSelf-heatingThermally enhanced drug deliveryTransdermal drug delivery

Identifiers

PMID42125256

DOI10.1016/j.mtbio.2026.103171

PMCPMC13158400

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.