ArticleJournal of oral biology and craniofacial research
Synergistic HA-tooth graft composite promotes rapid alveolar bone healing via IL-6 suppression and OCN enhancement.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Periodontitis leads to continuous alveolar bone destruction driven by persistent inflammation, particularly elevated interleukin-6 (IL-6). Bone healing after tooth extraction under periodontitis conditions is often impaired, highlighting the need for regenerative biomaterials that can regulate inflammation and support osteogenesis. The hyaluronic acid-bovine tooth graft (HA + BTG) combination has been proposed as a promising BioGel-Graft candidate for accelerated bone regeneration. Aim and objectives: This study aimed to evaluate IL-6 and osteocalcin (OCN) expression as biomarkers of alveolar bone healing in Methodology: Thirty-six male Wistar rats were allocated into three groups (control, HA, and HA + BTG). After periodontitis induction and tooth extraction, the treatment materials were applied to the extraction sockets. Tissue samples collected on days 14 and 21 were analyzed using immunohistochemistry for IL-6 and OCN, along with hematoxylin and eosin (H&E) staining to assess woven bone formation. Results: The HA + BTG group showed a significant reduction in IL-6 expression and a significant increase in OCN expression and woven bone area compared with the control (p < 0.05). An inverse trend between IL-6 and OCN reflected the transition from inflammation to osteogenesis. Conclusion: HA + BTG enhances alveolar bone regeneration by suppressing inflammation and stimulating osteoblastic activity, supporting its potential as an innovative gel-syringe biomaterial for regenerative alveolar bone therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.