Evidence map›Paper›PMID 42125182›Full record

ArticleSports medicine and health science2026

Higher BMI might increase risk of ankle-foot sprains: A mendelian randomization study.

Xicheng Gu, Xiao'ao Xue, Yi Li, Ziyi Chen, He Wang, Yinghui Hua

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sports medicine and health science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xicheng GuDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Xiao'ao XueDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Yi LiDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Ziyi ChenDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
He WangInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Yinghui HuaDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Although previous research has suggested that a greater body mass index (BMI) may be linked to a higher incidence of ankle-foot sprains, the causal relationship between BMI and these injuries has not been established. This study aims to determine the causal effect of BMI-related features on ankle-foot sprains using a two-sample Mendelian randomization (MR) analysis. Methods: Exposure single-nucleotide polymorphisms were collected from Genetic Investigation of Anthropometric Traits (GIANT Consortium) for BMI, hip circumference (HIP), hip circumference adjusted for BMI (HIP Results: BMI ( Conclusions: A genetic predisposition to higher BMI-related features can lead to a higher risk of ankle-foot sprains, providing new insight into how to prevent ankle-foot sprains in middle-aged and elderly people.

Indexed as

Ankle injuriesBody fat percentageBody mass indexMendelian randomization analysis

Identifiers

PMID42125182
PMCPMC13159448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.