ArticleEuropean heart journal. Imaging methods and practice2026
Polarization-sensitive optical coherence tomography-based fully-automated volumetric coronary fibrous cap characterization.
Article in European heart journal. Imaging methods and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: Accurate characterization of fibrous caps in coronary arteries allows more precise estimations of coronary plaque rupture risk. While intravascular imaging techniques offer high-resolution imaging, limitations in contrast and reliance on manual interpretation hinder large-scale, volumetric assessments of cap morphology. In this study, we present CapSeg, a fully automated computational pipeline for Methods and results: Using a dataset of 200 cross-sectional coronary IV-PS-OCT images, CapSeg's minimum cap thickness measurements were validated against manual annotations from two expert observers. Automated cap thickness measurements showed strong agreement with manual assessments (mean ± SD: CapSeg 131 ± 80 µm; Observer 1: 137 ± 84 µm; Observer 2: 144 ± 83 µm) demonstrating comparable limits of agreement relative to the inter-observer variability. The pipeline was applied to volumetric IV-PS-OCT data of 38 coronary lesions from patients with acute coronary syndrome (ACS, Conclusion: Overall, CapSeg enables fast, reproducible, and fully automated fibrous cap evaluation, laying the foundation for large-scale clinical studies and real-time intravascular imaging applications.
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