Evidence map›Paper›PMID 42124866›Full record

ArticleJournal of the American College of Emergency Physicians open2026

Prehospital Use of Lights and Sirens in Stroke Is Associated With Faster Door-to-CT Times but Not Door-to-Thrombolysis or Door-to-Endovascular Therapy Times.

Courtney D Wham, Daria Nicke, Ian S Espinoza, Logan Murphy, Geoffrey Sowitz, Stefan Sillau, Andra M Farcas, Michelle Leppert, Elizabeth Molina Kuna, Layne Dylla and 1 more

Abstract read
In one paragraph

Article in Journal of the American College of Emergency Physicians open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Courtney D WhamDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Daria NickeDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Ian S EspinozaDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Logan MurphyParamedic Division, Denver Health Medical Center, Denver, Colorado, USA.
Geoffrey SowitzDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Stefan SillauDepartment of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Andra M FarcasDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Michelle LeppertDepartment of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Elizabeth Molina KunaDepartment of Health Systems, Management, and Policy, Colorado School of Public Health, Aurora, Colorado, USA.
Layne DyllaDepartment of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
IMPACT Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Lights and sirens (L&S) during Emergency Medical Services (EMS) transport may shorten transport times and improve outcomes in acute stroke but carry significant roadway risk. This study assesses L&S and in-hospital stroke care, including door-to-CT, door-to-intravenous thrombolysis (IVT), door-to-endovascular thrombectomy (EVT), and discharge disposition. Methods: This retrospective cohort study analyzed data from 2020 to 2022, including adult patients identified by EMS as having suspected stroke and who had a final diagnosis of stroke or transient ischemic attack. Data were collected from the IMPACT network (70 EMS agencies, 30 hospitals, 2 states). Multivariable regression modeled the association between L&S and door-to-CT, door-to-IVT, and door-to-EVT times, controlling for confounders. Logistic regression modeled the association between L&S and discharge disposition, adjusting for confounders and in-hospital intervention. Results: Of 3,161 patients, 75.4% (n = 2384) were transported with L&S. Transport time with L&S was shorter than without (geometric mean 8.9 minutes [95% CI 8.7-9.1] vs 11.6 minutes [95% CI 11.0-12.1], Conclusion: While L&S were associated with faster door-to-CT times, they did not shorten time to IVT or EVT or improve discharge outcomes. These findings suggest that perceived urgency of L&S may prompt quicker imaging, but transport time savings are minimal and may not improve outcomes. Alternative EMS prenotification and hospital activation strategies merit consideration.

Identifiers

PMID42124866
PMCPMC13158396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.