ArticleRSC advances2026
New benzotriazole-sulfonate coupling reagents and applications.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Amide and ester bond formation is crucial in medicinal chemistry and relies heavily on coupling reagents in both academic and industry. We report the development of new cost-effective recyclable benzotriazole-sulfonate coupling reagents in a straightforward, rapid, and easy manner. The reagents efficiently activate carboxylic acids to form amides, esters, thioesters, and peptides, with excellent yields and high chirality retention. The reagent enables drug modifications and transformations, including aldoxime-to-nitrile and carboxylic acid-to-ketone conversions. The use of green solvents effectively minimizes the environmental impact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.