Advancements in the synthesis of naphthoxazine-3-one derivatives over the last two decades: a brief review.

Multicomponent reactions (MCRs) play a significant role in organic synthesis, medicinal chemistry and in material science, as they permit the formation of a single product from the strategic combination of more than two starting materials. Multicomponent reactions (MCRs) represent an attractive area of research for the efficient synthesis of highly functionalized, biological active and structurally diverse heterocyclic organic compounds. Synthesis of naphthoxazine-3-one derivatives is an important multicomponent reaction. Such derivatives are typically prepared in a one-pot from β-naphthol, aromatic aldehydes and urea in the presence of suitable catalyst thereby providing most efficient route for the synthesis of structurally diverse naphthoxazinone derivatives. Aromatic condensed naphthoxazinone derivatives represent an important class of functionalized building blocks. Naphthoxazinone derivatives are well-known by their significant biological activities such as anti-inflammatory, anti-ulcer, antibacterial, antipyretic, antifungal, antihypertensive,