Evidence map›Paper›PMID 42124832›Full record

ArticleRSC advances2026

Dual inhibition of neutrophil superoxide generation and elastase release

Dalia S El-Gamil, Mennatallah A Hammam, Michael Emad, Donia E Hafez, Mohamed El-Shazly, Yu-Cheng Chen, Yi-Hsuan Wang, Po-Hsiung Kung, Michal Korinek, Tsong-Long Hwang and 1 more

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Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dalia S El-GamilDepartment of Chemistry, Faculty of Pharmacy, Ahram Canadian University Cairo 12451 Egypt.
Mennatallah A HammamSchool of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation New Administrative Capital Cairo 11865 Egypt.
Michael EmadDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt mohammad.abdel-halim@guc.edu.eg.
Donia E HafezDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt mohammad.abdel-halim@guc.edu.eg.
Mohamed El-ShazlyDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University Cairo 11566 Egypt.
Yu-Cheng ChenCenter for Drug Research and Development, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333 Taiwan htl@mail.cgust.edu.tw.
Yi-Hsuan WangGraduate Institute of Natural Products, College of Medicine, Chang Gung University Taoyuan 333 Taiwan.
Po-Hsiung KungCenter for Drug Research and Development, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333 Taiwan htl@mail.cgust.edu.tw.
Michal KorinekGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University Kaohsiung 807 Taiwan.
Tsong-Long HwangCenter for Drug Research and Development, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333 Taiwan htl@mail.cgust.edu.tw.
Mohammad Abdel-HalimDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo Cairo 11835 Egypt mohammad.abdel-halim@guc.edu.eg.ORCID https://orcid.org/0000-0003-1326-4219

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of chalcone-based derivatives were synthesized and assessed for their ability to target neutrophil-driven inflammation. Strategic modifications on the 1,3-diaryl-prop-2-en-1-one scaffold, all bearing a methoxylated ring B, revealed two distinct anti-inflammatory profiles: inhibitors of both superoxide (SO) generation and elastase release, and selective SO inhibitors. Compound 17, featuring 3-methoxy and 2,4-dichlorophenyl substitutions, demonstrated the most potent dual inhibition (IC

Identifiers

PMID42124832
PMCPMC13159629

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.