Evidence map›Paper›PMID 42124762›Full record

ArticleCureus2026

Chronic Granulomatous Interstitial Nephritis Presenting Five Years After Intravesical Bacillus Calmette-Guérin Therapy: A Case Report and Literature Review.

Mehdi El Mansouri, Hanane Benali, Ismail Ait Elkihal, Nabil Hamouche, Mariam Chettati, Wafaa Fadili, Inass Laouad

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mehdi El MansouriNephrology, Mohammed VI University Center Hospital, Marrakech, MAR.
Hanane BenaliNephrology, Mohammed VI University Center Hospital, Marrakech, MAR.
Ismail Ait ElkihalNephrology, Mohammed VI University Center Hospital, Marrakech, MAR.
Nabil HamoucheNephrology, Mohammed VI University Center Hospital, Marrakech, MAR.
Mariam ChettatiNephrology, Mohammed VI University Center Hospital, Marrakech, MAR.
Wafaa FadiliNephrology, Mohammed VI University Center Hospital, Marrakech, MAR.
Inass LaouadNephrology, Mohammed VI University Center Hospital, Marrakech, MAR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravesical administration of Bacillus Calmette-Guérin (BCG) has been the standard treatment for non-muscle invasive bladder cancer (NMIBC).  Its efficacy in preventing recurrence and tumor progression has been well established; however, rare immune-mediated complications, particularly parenchymal renal involvement, pose significant diagnostic challenges. This report describes an exceptional case: that of a 73-year-old man who developed renal failure five years after his last BCG instillation. Histopathological examination revealed granulomatous interstitial nephritis. This case is remarkable for its exceptionally long and unusual latency period, which generally manifests within days to months in other patients.  After initiating corticosteroid therapy, the patient experienced partial renal recovery and stabilization of renal function during follow-up, highlighting the potential role of immunological mechanisms in delayed renal injury.  This study underscores the need for long-term renal monitoring in patients treated with BCG immunotherapy.

Indexed as

bacillus calmette-guerinbcg renal complicationsdrug-induced acute renal failuregranulomatous interstitial nephritisintravesical bcg therapylate bcg toxicitynon-caseating granulomanon-muscle invasive bladder cancersystemic bcg reaction

Identifiers

PMID42124762
PMCPMC13158628

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.