ReviewCureus2026
Evaluating the Safety of Creatine Monohydrate in Adolescents: A Systematic Review of Renal, Hepatic, and Cardiometabolic Outcomes.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creatine monohydrate is a widely used dietary supplement for performance enhancement among athletes and physically active individuals. Questions regarding its safety in adolescent populations remain an important consideration for clinicians and families. This systematic review evaluates the safety of creatine monohydrate supplementation in adolescent athletes and physically active youth. A comprehensive search of PubMed was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify relevant human studies published between 2015 and 2025. Inclusion criteria required original research involving adolescents or physically active youth receiving creatine monohydrate with reported safety outcomes. Five studies met eligibility criteria and were included in the final analysis, comprising randomized controlled trials and longitudinal cohort studies. Across diverse populations, including youth athletes and adolescents with medical conditions, creatine supplementation was generally well tolerated, with no consistent short-term safety signals reported in renal function, liver enzymes, or cardiometabolic risk markers within the study periods. No serious adverse events were attributed to supplementation. These findings summarize currently available evidence regarding creatine safety in adolescent and physically active pediatric populations and highlight the need for larger prospective studies with standardized dosing protocols and longer follow-up periods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.