ReviewCureus2026
Impact of Manipulation Under Anesthesia on Functional Outcomes Following Total Knee Arthroplasty: A Systematic Review of the Knee Society Score (KSS), Oxford Knee Score (OKS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative stiffness remains a significant complication following total knee arthroplasty (TKA), affecting functional recovery and patient satisfaction. Manipulation under anesthesia (MUA) is commonly employed when conservative measures fail, yet the impact on patient-reported outcomes remains unclear. This systematic review evaluated functional outcomes following MUA, focusing on the Knee Society Score (KSS), Oxford Knee Score (OKS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. A comprehensive search of PubMed, Embase, Scopus, and the Cochrane Library was conducted up to February 1, 2026, in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Six studies, including retrospective and prospective cohorts and a systematic review, were included. Early MUA (<8-12 weeks) consistently achieved a superior range of motion (ROM) gains (+25° to +34°) compared to delayed interventions. Functional outcomes showed modest short-term improvements with sustained long-term benefits, and complications were rare. While ROM gains were reliably achieved, patient-perceived functional recovery depended on pain control, rehabilitation adherence, and individual factors. Early and standardized MUA is effective for improving mobility and functional recovery after TKA. Future high-quality prospective studies are warranted to refine timing, standardize techniques, and clarify the relationship between mechanical improvements and patient-centered outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.