ArticleMedeniyet medical journal2026
Dual Targeting Strategy: Colchicine and Paclitaxel Combination Against Prostate Cancer Cells Colchicine-Paclitaxel Synergy in Prostate Cancer.
Article in Medeniyet medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Objective: Prostate cancer is the leading male malignancy. Despite therapeutic advances, drug resistance remains a major obstacle, leading many patients to develop castration-resistant prostate cancer. This study investigates the combined effects of the microtubule-targeting agents colchicine and paclitaxel on DU145 prostate cancer cells. Methods: Cell viability was evaluated across a range of doses of colchicine and paclitaxel to determine the IC Results: Monotherapy with colchicine and paclitaxel indicated dose- and time-dependent cytotoxicity in DU145 cells. Notably, IC Conclusions: These preliminary findings demonstrate that the colchicine and paclitaxel combination exhibits potent synergistic effects, particularly at low doses (IC
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