ArticlebioRxiv : the preprint server for biology2026
Unique Amygdala Signatures and Shared Prefrontal Deficits in Autism: Mapping Social Heterogeneity via Naturalistic functional Magnetic Resonance Imaging.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Naturalistic fMRI provides an ecologically valid window into social brain function, yet binary diagnostic labels may obscure neural signatures linked to the continuous spectrum of social deficits. We investigated whether social brain alterations in autism spectrum disorder (ASD) follow a categorical, dimensional, or "dual-track" architecture. Methods: We analyzed fMRI data from 428 youth (262 ASD, 166 typically developing; ages 5-22) watching two films: Results: During Conclusions: While core social-motivational hubs reflect overlapping diagnostic and dimensional deficits, the amygdala and secondary visual patterns provide distinct, dimension-specific signatures of social impairment. This variance partitioning approach supports a Research Domain Criteria (RDoC) framework, highlighting the necessity of integrating dimensional assessments and narrative complexity to characterize the neural architecture of autism.
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