Evidence map›Paper›PMID 42124705›Full record

ArticlebioRxiv : the preprint server for biology2026

CBASS limits bacteriophage production while maintaining cell viability in

Erin Huiting, Bruce Wang, Esther Shmidov, Sriharshita Musunuri, Zemer Gitai, Joseph Bondy-Denomy

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Erin HuitingDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-5454-2679
Bruce WangLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Esther ShmidovDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-9101-6168
Sriharshita MusunuriDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-6581-2494
Zemer GitaiDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.ORCID 0000-0002-3280-6178
Joseph Bondy-DenomyDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-4909-9481

Funding

Medical Scientist Training Program (T32 NRSA Training Grant)T32GM141323 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aimee Kao · 2021 to 2026
$10.5M
Quantitavie and Computational Biology Graduate ProgramT32HG003284 · NHGRI · PRINCETON UNIVERSITY · PI Joshua Michael Akey, Stanislav Y. Shvartsman · 2004 to 2026
$9.9M
Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
A single-cell approach to developing non-traditional antibioticsDP1AI190418 · NIAID · PRINCETON UNIVERSITY · PI Zemer Gitai · 2024 to 2026
$5.7M
Formation and function of cell curvature in Vibrio choleraeR01GM143227 · NIGMS · PRINCETON UNIVERSITY · PI GITAI, ZEMER · 2022 to 2025
$1.3M
Identifying the mechanism of bacteriophage detection by cyclic-oligonucleotide signaling systemsR21AI168811 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BONDY-DENOMY, JOSEPH · 2022 to 2023
$444k
NHGRI NIH HHS T32 HG003284NIAID NIH HHS DP1 AI190418NIAID NIH HHS R21 AI168811NIAID NIH HHS T32 AI060537NIGMS NIH HHS R01 GM143227NIGMS NIH HHS T32 GM141323
6 · The paper itself

Abstract

CBASS is an immune pathway that recognizes phage infection and generates cyclic nucleotide signals, which directly activate effectors that stop phage replication. Membrane-acting effectors are proposed to induce cell death to prevent phage replication; however, this mechanism has not been assessed with endogenous expression levels of the effector. We therefore sought to determine the cell viability outcomes of the CBASS phospholipase effector (CapV) upon activation with 3',3'-cGAMP signals in

Indexed as

3’,3’-cGAMPabortive infectionanti-phage immunityCapVCBASScell viabilityPseudomonas aeruginosa

Identifiers

PMID42124705
PMCPMC13160051

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.