Evidence map›Paper›PMID 42124694›Full record

ArticlebioRxiv : the preprint server for biology2026

Peripheral metabolic dysfunction drives sleep disruption in TDP-43 proteinopathy.

Anyara Rodriguez, Jenny Luong, Samuel J Belfer, Oksana Shcherbakova, Jaclyn Durkin, Pinky Kain, Arjun Sengupta, Alexandra E Perlegos, Farheen Akhtar, Daniel J Boehmler and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anyara RodriguezDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jenny LuongDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Samuel J BelferDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Oksana ShcherbakovaDepartment of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jaclyn DurkinDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Pinky KainDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Arjun SenguptaDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0003-2210-1876
Alexandra E PerlegosDepartment of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Farheen AkhtarDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Daniel J BoehmlerDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zhecheng JinDepartment of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Aalim M WeljieInstitute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Nancy M BoniniDepartment of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0003-0226-5291
Matthew S KayserDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0003-2359-4967

Funding

Deciphering the molecular interplay of sleep and neurodegeneration with DrosophilaR01AG071777 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Nancy M Bonini, MATTHEW S KAYSER · 2022 to 2026
$3.1M
NIA NIH HHS R01 AG071777
6 · The paper itself

Abstract

Sleep disruption is an early and prevalent feature of neurodegenerative disease, commonly attributed to neuronal circuit dysfunction or cell loss. However, sleep is tightly coupled to metabolic state, raising the possibility that systemic metabolic abnormalities contribute to disease-associated sleep phenotypes. Using

Identifiers

PMID42124694
PMCPMC13160110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.