Evidence map›Paper›PMID 42124679›Full record

ArticlebioRxiv : the preprint server for biology2026

PFOA induced metabolic and immune perturbations in a SARS-2 infection model.

Deanna N Lanier, Dawne Rowe Haas, Mario Uchimiya, Cheryl Jones, Scott Johnson, Kaori Sakamoto, Jessie R Chappel, Allison N Fry, Franklin E Leach, Jamie DeWitt and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Deanna N LanierInstitute of Bioinformatics, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-2518-7241
Dawne Rowe HaasDepartment of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.ORCID 0000-0002-4637-373X
Mario UchimiyaComplex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA.
Cheryl JonesDepartment of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
Scott JohnsonDepartment of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
Kaori SakamotoDepartment of Pathology, College of Veterinary Medicine, Athens, GA, USA.
Jessie R ChappelBioinformatics Research Center, Department of Biological Sciences, North Carolina State University, Raleigh, NC 27606, USA.
Allison N FryDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Franklin E LeachDepartment of Chemistry, University of Georgia, Athens, GA 30602, USA.
Jamie DeWittDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97333, USA.
Tracey WoodliefDepartment of Pharmacology and Toxicology, East Carolina University, Greenville, NC, 27858, USA.
David A GaulSchool of Chemistry and Biochemistry and Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology Atlanta, GA 30332, USA.
Erin S BakerDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0001-5246-2213
Facundo M FernándezSchool of Chemistry and Biochemistry and Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology Atlanta, GA 30332, USA.ORCID 0000-0002-0302-2534
Stephen M TompkinsDepartment of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.ORCID 0000-0002-1523-5588
Arthur S EdisonInstitute of Bioinformatics, University of Georgia, Athens, Georgia, USA.

Funding

Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Efstratios Pistikopoulos · 2017 to 2026
$21.2M
Portal for Open Computational Metabolomics Tools - Yr 4 U2C SupplementU2CES030167 · NIEHS · UNIVERSITY OF GEORGIA · PI EDISON, ARTHUR S · 2018 to 2021
$4.2M
Platform for in vivo Metabolism - Equipment SupplementR35GM148240 · NIGMS · UNIVERSITY OF GEORGIA · PI ARTHUR S EDISON · 2023 to 2026
$2.2M
NIEHS NIH HHS P42 ES027704NIEHS NIH HHS U2C ES030167NIGMS NIH HHS R35 GM148240
6 · The paper itself

Abstract

This study evaluates the impact of PFOA exposure on the metabolome and immune response to SARS-2 using a ferret model. Ferrets were separated into control or PFOA-exposed groups (10/mg/kg/day) and challenged with SARS-2. Longitudinal analyses encompassing clinical assessments, serological profiling, histopathology, and untargeted nuclear magnetic resonance (NMR) metabolomics revealed significant metabolic and immunological perturbations. We found prominent effects of PFOA exposure on metabolism, which resulted in altered metabolic responses to SARS-2 infection. PFOA exposure was also associated with impaired immune function, as evidenced by decreased serum IgG levels, increased viral loads, and prolonged peak infectivity. These findings underscore the consequences of PFOA exposure on host metabolism and immunity during infectious diseases.

Identifiers

PMID42124679
PMCPMC13160007

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.