Evidence map›Paper›PMID 42124670›Full record

ArticlebioRxiv : the preprint server for biology2026

Hypoxia-activated

Björn Perder, Yu Xia, Jun Yao, Miaoyan Qiu, Alvin Gea Chen Yao, Muhammad Naeem, Paul Zumbo, Ignace Van der Wee, Avi Yakubov, Kazu Kikuchi and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Björn PerderCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Yu XiaCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Jun YaoCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Miaoyan QiuCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Alvin Gea Chen YaoCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Muhammad NaeemCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Paul ZumboApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.
Ignace Van der WeeCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Avi YakubovCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Kazu KikuchiDepartment of Cardiac Regeneration Biology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Doron BetelApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8006-7752
Todd EvansCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Michael R HarrisonCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.
Jingli CaoCardiovascular Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-5938-6604

Funding

Mechanisms controlling epicardial-dependent promotion of heart regeneration in zebrafish.R01HL155607 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jingli Cao · 2021 to 2026
$2.9M
Spatiotemporal regulation of polyploidy in zebrafish cardiac tissue regenerationR01HL166518 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jingli Cao · 2023 to 2026
$2.8M
Lymphatic Support of Neurogenesis and RegenerationR01NS126209 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Michael Harrison · 2023 to 2026
$1.8M
American Heart Association-American Stroke Association 23TPA1077772American Heart Association-American Stroke Association 941434NHLBI NIH HHS R01 HL155607NHLBI NIH HHS R01 HL166518NINDS NIH HHS R01 NS126209
6 · The paper itself

Abstract

The epicardium is a crucial source of progenitor cells and paracrine signals that support heart development and regeneration. However, the molecular mechanisms that guide epicardial cell fate decisions remain incompletely understood. Here, we identify the transcription factor Scleraxis a (encoded by

Indexed as

col18a1acoronary angiogenesisepicardial progenitorshypoxiascleraxis

Identifiers

PMID42124670
PMCPMC13160011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.