Evidence map›Paper›PMID 42124667›Full record

ArticlebioRxiv : the preprint server for biology2026

Modeling patient variants of

Eric L Bogenschutz, Cynthia Carpenter, Ameleen Wong, Kristina Palmer, Aalekh Mehta, Yannick Ledermann, Caleb Heffner, Kathy J Snow, Carol Bult, Yufeng Shen and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eric L BogenschutzThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0003-3642-1707
Cynthia CarpenterThe Jackson Laboratory, Bar Harbor, ME, USA.
Ameleen WongThe Jackson Laboratory, Bar Harbor, ME, USA.
Kristina PalmerThe Jackson Laboratory, Bar Harbor, ME, USA.
Aalekh MehtaPediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA, USA.ORCID 0009-0000-7170-9568
Yannick LedermannPediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA, USA.ORCID 0009-0008-5991-6415
Caleb HeffnerThe Jackson Laboratory, Bar Harbor, ME, USA.
Kathy J SnowThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0009-0006-5565-0619
Carol BultThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0001-9433-210X
Yufeng ShenDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-1299-5979
Patricia K DonahoePediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-5502-4497
Samuel P RowbothamPediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-0618-1132
Frances A HighPediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA, USA.ORCID 0009-0000-5614-1257
Wendy K ChungDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3438-5685
Stephen A MurrayThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-0594-1702

Funding

The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2)UM1OD023222 · OD · JACKSON LABORATORY · PI ROBERT E BRAUN, Stephen A Murray · 2016 to 2026
$47.2M
THE DROSOPHILA GENETICS AND RNAI CORE (THE FLY CORE)P01HD068250 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, WENDY K, DONAHOE, PATRICIA K · 2011 to 2022
$17.1M
REPRODUCTIVE BIOLOGYT32HD007065 · NICHD · JACKSON LABORATORY · PI BRAUN, ROBERT E · 1985 to 2020
$2.6M
Functional Validation of Novel Variants Associated with Congenital Diaphragmatic HerniaR01HD115718 · NICHD · JACKSON LABORATORY · PI Frances Arianwen High, Stephen A Murray · 2024 to 2026
$2.2M
Understanding the impact of targeting the epigenetic regulation of lung stem cells in congenital lung diseaseR03HD112717 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI ROWBOTHAM, SAMUEL PHILIP · 2023 to 2023
$167k
Dissecting the Genetic Basis of Congenital Diaphragmatic Hernias in MiceF32HD107804 · NICHD · JACKSON LABORATORY · PI BOGENSCHUTZ, ERIC · 2022 to 2023
$137k
NICHD NIH HHS F32 HD107804NICHD NIH HHS P01 HD068250NICHD NIH HHS R01 HD115718NICHD NIH HHS R03 HD112717NICHD NIH HHS T32 HD007065NIH HHS UM1 OD023222
6 · The paper itself

Abstract

Congenital diaphragmatic hernia (CDH) is a severe congenital anomaly characterized by impairment of both diaphragm and lung development

Identifiers

PMID42124667
PMCPMC13160174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.