Evidence map›Paper›PMID 42124625›Full record

ArticlebioRxiv : the preprint server for biology2026

Sphingolipid regulation by yeast Mdm1 supports adaptive remodeling of the methionine transporter Mup1.

Daniel Adebayo, Eseiwi Obaseki, Kashvi Vasudeva, Marwa Aboumourad, Scott Miller, Anne Ostermeyer-Fay, Daniel Canals, Xun Bao, Jing Li, Hanaa Hariri

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Daniel AdebayoBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Eseiwi ObasekiBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Kashvi VasudevaBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Marwa AboumouradBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Scott MillerBiological Sciences Department, Wayne State University, Detroit, MI, USA.
Anne Ostermeyer-FayBiological Mass Spectrometry Shared Resource, Stony Brook University School of Medicine, Stony Brook, NY.
Daniel CanalsBiological Mass Spectrometry Shared Resource, Stony Brook University School of Medicine, Stony Brook, NY.
Xun BaoDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
Jing LiDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
Hanaa HaririBiological Sciences Department, Wayne State University, Detroit, MI, USA.ORCID 0009-0008-4044-9597

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
Subcellular mechanisms coupling lipid synthesis and methionine metabolismR35GM150892 · NIGMS · WAYNE STATE UNIVERSITY · PI Hanaa Hariri · 2023 to 2026
$1.5M
NCI NIH HHS P30 CA022453NIGMS NIH HHS R35 GM150892
6 · The paper itself

Abstract

Membrane lipid composition influences endocytic remodeling of nutrient transporters, yet how lipid metabolism is spatially coordinated to support sustained adaptation to nutrient limitations remains unclear. Here, we investigated whether the ER-vacuole tether Mdm1 links sphingolipid homeostasis to regulation of the high-affinity methionine permease Mup1 in budding yeast. To test this, we examined Mup1 trafficking, amino acid homeostasis, and sphingolipid composition in

Identifiers

PMID42124625
PMCPMC13160028

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.