Evidence map›Paper›PMID 42124622›Full record

ArticlebioRxiv : the preprint server for biology2026

The methodological foundations of lesion network mapping remain sound.

Shan Siddiqi, Andreas Horn, Frederic L W V J Schaper, Sanaz Khosravani, Alexander Li Cohen, Juho Joutsa, John D Rolston, Michael A Ferguson, Samuel B Snider, Anderson M Winkler and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shan SiddiqiCenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, Neurosurgery, and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.ORCID 0000-0002-0967-9289
Andreas HornCenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, Neurosurgery, and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.ORCID 0000-0002-0695-6025
Frederic L W V J SchaperCenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, Neurosurgery, and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.
Sanaz KhosravaniCenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, Neurosurgery, and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.ORCID 0009-0008-2469-5325
Alexander Li CohenCenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, Neurosurgery, and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.ORCID 0000-0001-6557-5866
Juho JoutsaTurku Brain and Mind Center, Clinical Neurosciences, University of Turku; Neurocenter, Turku University Hospital, Finland.ORCID 0000-0002-3457-9415
John D RolstonCenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, Neurosurgery, and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.ORCID 0000-0002-8843-5468
Michael A FergusonCenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, Neurosurgery, and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.ORCID 0000-0002-8645-0082
Samuel B SniderCenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, Neurosurgery, and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.ORCID 0000-0002-6965-7890
Anderson M WinklerDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville TX, USA.ORCID 0000-0002-4169-9781
Harith AkramUCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.ORCID 0000-0002-2899-628X
Stephen M SmithUniversity of Oxford, Oxford, UK.ORCID 0000-0001-8166-069X
Thomas E NicholsUniversity of Oxford, Oxford, UK.ORCID 0000-0002-4516-5103
Karl FristonUCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.ORCID 0000-0001-7984-8909
Aaron D BoesDepartments of Pediatrics, Neurology, Psychiatry, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-7865-9257
Michael D FoxCenter for Brain Circuit Therapeutics, Departments of Neurology, Psychiatry, Neurosurgery, and Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA.ORCID 0000-0001-8848-6399

Funding

BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5M
Workforce Development CoreU54HG013247 · NHGRI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI John Blangero · 2023 to 2026
$10.5M
Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9M
VIPS: Vascular Effects of Infection in Pediatric StrokeR01NS062820 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEVEBER, GABRIELLE ALINE, FULLERTON, HEATHER J · 2009 to 2013
$6.6M
Toward Connectomic Deep Brain Stimulation in Obsessive Compulsive DisorderR01MH130666 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.9M
Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitR01NS127892 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.4M
Seizures and Children's Outcomes after Stroke (SCOUTS)R01NS119896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Christine K. Fox · 2022 to 2026
$3.4M
Investigating the neural mechanisms of repetitive brain stimulation with invasive and noninvasive electrophysiology in humansR01MH132074 · NIMH · STANFORD UNIVERSITY · PI Aaron D Boes, Corey J Keller · 2023 to 2026
$3.1M
A causal wiring diagram of transdiagnostic brain functionsR01MH136248 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI Shan Siddiqi · 2024 to 2026
$2.3M
Optimized methods for measuring brain excitability in depressionR01MH139650 · NIMH · STANFORD UNIVERSITY · PI Aaron D Boes, Corey J Keller · 2025 to 2026
$1.5M
Optimizing Neuromodulation Therapies for Epilepsy: Identifying the Right Patient, Right Place, and Right Time for StimulationR01NS136297 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI JOHN D ROLSTON · 2025 to 2026
$1.3M
Enhancing PALM with novel statistical methods, cloud integration, parallelization, and imaging standardsR01MH139547 · NIMH · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI ANDERSON M WINKLER · 2025 to 2026
$988k
NHGRI NIH HHS U54 HG013247NIMH NIH HHS K23 MH121657NIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH130666NIMH NIH HHS R01 MH132074NIMH NIH HHS R01 MH136248NIMH NIH HHS R01 MH138425NIMH NIH HHS R01 MH139547NIMH NIH HHS R01 MH139650NIMH NIH HHS R01 MH140916NIMH NIH HHS R21 MH126271NINDS NIH HHS R01 NS062820NINDS NIH HHS R01 NS119896NINDS NIH HHS R01 NS127892NINDS NIH HHS R01 NS136297NINDS NIH HHS R21 NS123813NINDS NIH HHS UM1 NS132358
6 · The paper itself

Abstract

Lesion network mapping (LNM) and related techniques have been used in over 200 studies, primarily to test whether anatomically distributed lesions that cause the same symptom fall within a common brain network. A recent article

Identifiers

PMID42124622
PMCPMC13160081

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.