Evidence map›Paper›PMID 42124615›Full record

ArticlebioRxiv : the preprint server for biology2026

TNAP and PHOSPHO1 function synergistically to afford critical control over the mineralisation of the postnatal murine skeleton.

Lucie E Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N Jayash, Natalie Crump, Lucinda Ae Evans, Maya Karmali, Worachet Promruk, Claire E Clarkin and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Lucie E BourneCentre for Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, BN2 4GT, UK.
Aikta SharmaDepartment of Mechanical Engineering, University College London, London, WC1E 7JE, UK.
Scott DillonYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Jacob KeenSchool of Biological Sciences, University of Southampton, Southampton, SO17 1BJ, UK.
Soher N JayashThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Natalie CrumpCentre for Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, BN2 4GT, UK.
Lucinda Ae EvansFaculty of Life Sciences & Medicine, Kings College London, London, SE1 1UL, UK.
Maya KarmaliCentre for Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, BN2 4GT, UK.
Worachet PromrukThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Claire E ClarkinSchool of Biological Sciences, University of Southampton, Southampton, SO17 1BJ, UK.
Sonoko NarisawaHuman Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Louise StephenThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Brian L FosterDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-3444-0576
José Luis MillánHuman Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Colin FarquharsonThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Katherine A StainesCentre for Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, BN2 4GT, UK.

Funding

Identifying Novel Mechanisms for Dentoalveolar Mineralization Defects in X-linked HypophosphatemiaR01DE032334 · NIDCR · OHIO STATE UNIVERSITY · PI Brian Lee Foster · 2022 to 2026
$2.5M
NIDCR NIH HHS R01 DE032334
6 · The paper itself

Abstract

Biomineralisation is essential for skeletal integrity, yet the synergistic roles of tissue non-specific alkaline phosphatase (TNAP) and PHOSPHO1 in postnatal bone mineralisation remain poorly defined. To decipher this, we generated a novel murine model in which

Indexed as

biomineralisationbonemurine modelPhospho1Tissue non-specific alkaline phosphatase

Identifiers

PMID42124615
PMCPMC13160159

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.