Evidence map›Paper›PMID 42124610›Full record

ArticlebioRxiv : the preprint server for biology2026

A Hidden Binding Pocket in the β- ketoacyl-ACP Synthase FabB.

Ziran Jiang, Anika Friedman, Annette Thompson, Samuel J Andrzejewski, Kathryn Mains, Banumathi Sankaran, Michael D Burkart, Michael R Shirts, Jerome M Fox

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziran JiangDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, California, 92093, United States.
Anika FriedmanDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, 3415 Colorado Avenue, Boulder, Colorado, 80303, United States.
Annette ThompsonDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, 3415 Colorado Avenue, Boulder, Colorado, 80303, United States.
Samuel J AndrzejewskiDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, 3415 Colorado Avenue, Boulder, Colorado, 80303, United States.
Kathryn MainsDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, 3415 Colorado Avenue, Boulder, Colorado, 80303, United States.
Banumathi SankaranMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA, 94720, United States.
Michael D BurkartDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, California, 92093, United States.ORCID 0000-0002-4472-2254
Michael R ShirtsDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, 3415 Colorado Avenue, Boulder, Colorado, 80303, United States.ORCID 0000-0003-3249-1097
Jerome M FoxDepartment of Chemical and Biological Engineering, University of Colorado, Boulder, 3415 Colorado Avenue, Boulder, Colorado, 80303, United States.

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Protein-Protein Interactions in Natural Product BiosynthesisR01GM095970 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2012 to 2025
$5.9M
NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM095970
6 · The paper itself

Abstract

Assembly-line enzymes carry out multi-step synthesis of diverse metabolites by using a handful of catalytic motifs in which minor structural differences control substrate specificity and reaction order. Here we examine differences in substrate binding to FabB and FabF, the two β-ketoacyl-ACP synthases (KSs) responsible for fatty acid elongation in

Indexed as

Assembly-line enzymesBiomolecular plasticityFatty acid synthaseKetosynthaseProtein-protein interactions

Identifiers

PMID42124610
PMCPMC13160055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.