ArticleResearch and reports in urology2026
Real-World Predictors of Response to Immunotherapy in Metastatic Renal Cell Carcinoma: The Emerging Role of the Urologist in Immuno-Oncology.
Article in Research and reports in urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Immunotherapy has transformed the treatment of metastatic renal cell carcinoma (mRCC), with urologists playing a central role in systemic treatment selection through multidisciplinary decision-making, patient selection, and treatment sequencing. Identifying predictors of response is essential to personalize therapy and improve outcomes. Material and Methods: We conducted a retrospective, single-center study of 32 patients with mRCC who received immunotherapy: 15 received first-line nivolumab-ipilimumab, 3 pembrolizumab-axitinib, 13 second-line nivolumab, and 1 third-line nivolumab. Clinical, histological, and prognostic variables (International Metastatic Renal Cell Carcinoma Database Consortium (IMDC), Meet-URO, FAN score), and blood biomarkers (neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), eosinophil percentage) were assessed using Kaplan-Meier analysis with Log rank tests and Cox regression. Given the small sample size, results should be interpreted with caution. Results: A total of 32 patients were included, with the majority classified as IMDC intermediate risk. The Meet-URO score showed superior prognostic value for overall survival compared with IMDC (median 21 vs. 1-2 months across groups; 95% CI 1.83-20.17; p=0.043). A post-treatment NLR below 2.44 predicted improved progression-free survival (median 17 vs. 7 months; 95% CI 7.4-26.2; p=0.014) and remained independently significant. Neither FAN score nor eosinophil percentage provided prognostic discrimination. No survival differences were observed between treatment lines. Cytoreductive nephrectomy (78%) was associated with longer progression-free survival (9 vs. 3 months; HR: 3.72, 95% CI 1.15-12.02; p=0.028) and overall survival (21 vs. 3 months; HR 4.03, 95% CI 1.14-14.19; p=0.030). Conclusion: Cytoreductive nephrectomy, early NLR, and the Meet-URO score may have potential value for risk stratification in patients with mRCC receiving immunotherapy. In a real-world urology-led setting, these factors may support clinical decision-making and treatment selection. These findings should be considered exploratory and hypothesis-generating, given the limited sample size, and warrant confirmation in larger prospective studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.