Evidence map›Paper›PMID 42124487›Full record

ArticleChembiochem : a European journal of chemical biology2026

Engineering an Acyl-CoA Ligase With Enhanced Activity Toward Synthetic CoA Alternatives.

Jared R Cossin, Sarah A Taboada, Gavin J Williams

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Engineering an Acyl-CoA Ligase With Enhanced Activity Toward Synthetic CoA Alternatives.Chembiochem : a European journal of chemical biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jared R CossinNorth Carolina State University, Raleigh, North Carolina, USA.
Sarah A TaboadaNorth Carolina State University, Raleigh, North Carolina, USA.
Gavin J WilliamsNorth Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0003-2172-9063

Funding

Designer biosensors for directed evolution of macrolide biosynthetic enzymesR01GM124112 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CROPP, THOMAS ASHTON, WILLIAMS, GAVIN J · 2018 to 2021
$1.1M
National Institutes of General Medical Sciences GM124112NIGMS NIH HHS R01 GM124112
6 · The paper itself

Abstract

Fatty acyl-coenzyme A (CoA) thioesters are indispensable intermediates in primary metabolism and essential building blocks for biosynthetic pathways yielding fuels, fine chemicals, and pharmaceuticals. However, large-scale production of acyl-CoAs is frequently constrained by the intracellular availability and high cost of CoA, motivating the development of alternative strategies for precursor generation. Here, we report the engineering of the acylCoA ligase AcsA

Indexed as

Acyl Coenzyme ACoenzyme ACoenzyme A LigasesProtein EngineeringKineticsSubstrate SpecificityAcyl Coenzyme ACoenzyme ACoenzyme A Ligasesacyl‐CoA ligasesbiocatalysisbiosynthesisdirected evolutionpolyketides

Identifiers

PMID42124487
PMCPMC13168922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.