Evidence map›Paper›PMID 42124433›Full record

ArticleChemistry & biodiversity2026

Trichostatin Analogues From the Karst Cave Associated Streptomyces sp. DX6D14.

Li Yang, Huan Xie, Qing-Yun Ma, Qing-Yi Xie, Jiao-Cen Guo, Hao-Fu Dai, Yu-E Hao, You-Xing Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li YangHaikou Key Laboratory for Research and Utilization of Tropical Natural Products & National Key Laboratory For Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China.
Huan XieDepartment of Public Health Laboratory Sciences, School of Public Health, Heng-yang Medical School, University of South China, Hengyang, Hunan, China.
Qing-Yun MaHaikou Key Laboratory for Research and Utilization of Tropical Natural Products & National Key Laboratory For Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China.
Qing-Yi XieHaikou Key Laboratory for Research and Utilization of Tropical Natural Products & National Key Laboratory For Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China.
Jiao-Cen GuoHaikou Key Laboratory for Research and Utilization of Tropical Natural Products & National Key Laboratory For Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China.
Hao-Fu DaiHaikou Key Laboratory for Research and Utilization of Tropical Natural Products & National Key Laboratory For Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China.
Yu-E HaoDepartment of Public Health Laboratory Sciences, School of Public Health, Heng-yang Medical School, University of South China, Hengyang, Hunan, China.
You-Xing ZhaoHaikou Key Laboratory for Research and Utilization of Tropical Natural Products & National Key Laboratory For Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China.ORCID https://orcid.org/0000-0002-8107-2510

Funding

Chinese Academy of Tropical Agricultural Sciences for Science and Technology CARS-21Hainan Provincial Natural Science Foundation of China 326ZD1015Hubei Provincial Natural Science Foundation and Xiangyang of China 2025AFD068National Natural Science Fund of China 82304349Special Financial Project of the Ministry of Agriculture and Rural Areas NFZX2024
6 · The paper itself

Abstract

Six new trichostatin analogs, designated karstmycins I-M (1-6), together with eight known congeners (7-14), were obtained from Streptomyces sp. DX6D14 isolated from the soil of the karst cave. The structures of the new compounds were elucidated through spectroscopic analysis, including high-resolution electron spray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculations. All the isolates were evaluated for antibacterial and cytotoxic activities.

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsHydroxamic AcidsStreptomycesCavesCell Line, TumorCircular DichroismHumansMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMolecular ConformationAnti-Bacterial AgentsAntineoplastic AgentsHydroxamic Acids

Identifiers

PMID42124433
PMCPMC13380993

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