Evidence map›Paper›PMID 42124070›Full record

ArticleNutrients2026

Early-Life High-Fat-Diet Exposure Induced Pre-Puberty Obesity-Related MASLD via Autophagy-Mediated Ferroptosis in Male C57BL/6J Mice.

Zihan Zhang, Yan Wu, Xiaoqing Wu, Yiyi Zhao, Chen Liang, Jinran Xu, Zhouqi Nie, Shuhan Liu, Tianni Lv, Ming Wu and 1 more

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In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Zihan ZhangKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, China Medical University, Ministry of Education, Shenyang 110021, China.
Yan WuSchool of Public Health, China Medical University, Shenyang 110021, China.
Xiaoqing WuDepartment of Maternal and Child Health, School of Public Health, China Medical University, Shenyang 110021, China.
Yiyi ZhaoSecond Clinical College, China Medical University, Shenyang 110021, China.
Chen LiangSchool of Public Health, China Medical University, Shenyang 110021, China.
Jinran XuSecond Clinical College, China Medical University, Shenyang 110021, China.
Zhouqi NieSchool of Medical Humanities, China Medical University, Shenyang 110021, China.
Shuhan LiuSchool of Nursing, China Medical University, Shenyang 110021, China.
Tianni LvSecond Clinical College, China Medical University, Shenyang 110021, China.
Ming WuLiaoning Provincial Center for Disease Control and Prevention, Shenyang 110172, China.
Lingling ZhaiKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, China Medical University, Ministry of Education, Shenyang 110021, China.

Funding

Innovation and Entrepreneurship Training Program for College Students of China Medical University 202510159037
6 · The paper itself

Abstract

objectivesExposure to high-fat diets in early life plays an important role in metabolic dysfunction-associated steatotic liver disease (MASLD); however, the mechanism remains unclear. In this study, we explore the role of autophagy and ferroptosis in pre-puberty obesity-related MASLD caused by high-fat diets in early life.

methodsTwenty-four male C57BL/6J mice were fed over a 6-week period, and were divided into three groups: control, lactation HFD, and lactation + post-weaning HFD group. AML12 cells were treated with 0.5 mM free fatty acids (palmitic acid:oleic acid = 1:2) for 24 h to establish an in vitro model. Metabolism, autophagy, and ferroptosis-related indicators were detected.

resultsCompared to the control group, the body weight, droplet deposition of the liver, Fe

conclusionsEarly-life high-fat-diet exposure induced pre-puberty obesity-related MASLD, possibly via autophagy, which may be regulated by the AMPK/mTOR/ULK1 pathway and mediated by ferroptosis in male mice.

Indexed as

AutophagyDiet, High-FatFatty LiverFerroptosisNon-alcoholic Fatty Liver DiseaseObesityAMP-Activated Protein KinasesAnimalsAutophagy-Related Protein-1 HomologCell LineLactationLiverMaleMiceMice, Inbred C57BLSignal TransductionAMP-Activated Protein KinasesAutophagy-Related Protein-1 HomologTOR Serine-Threonine KinasesUlk1 protein, mouseautophagyearly-lifeferroptosismetabolic dysfunction-associated steatotic liver diseaseobesity

Identifiers

PMID42124070
PMCPMC13164880

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.