Evidence map›Paper›PMID 42124060›Full record

ArticleNutrients2026

Adoption of an Early Enteral Nutrition Feeding Protocol in Patients Receiving an Allogeneic Stem Cell Transplant.

Nikki Spurgeon, Jana Ponce, Peyton Hainline, Michael Haddadin, Vijaya Raj Bhatt, Christopher Wichman, Emily Thompson, Md Saif Uddin Rashed, Jacque Schwartz, Corri Hanson and 1 more

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Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Nikki SpurgeonDepartment of Clinical Nutrition, Nebraska Medicine, Omaha, NE 68198, USA.
Jana PonceDepartment of Medical Sciences, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-1040-8750
Peyton HainlineDepartment of Clinical Nutrition, Nebraska Medicine, Omaha, NE 68198, USA.
Michael HaddadinDepartment of Internal Medicine, Division of Hematology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0009-0000-9186-5648
Vijaya Raj BhattDepartment of Internal Medicine, Division of Hematology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-2513-0533
Christopher WichmanCollege of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Emily ThompsonDepartment of Nutrition and Food Service, Sanford Children's Hospital, Sioux Falls, SD 57117, USA.
Md Saif Uddin RashedCollege of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Jacque SchwartzDepartment of Clinical Nutrition, Nebraska Medicine, Omaha, NE 68198, USA.
Corri HansonDepartment of Medical Sciences, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Mariah JacksonDepartment of Medical Sciences, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-5225-6647

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute Graft versus Host Disease (aGvHD) is a serious complication of allogeneic stem cell transplantation (Allo-SCT) associated with substantial morbidity and mortality. Enteral nutrition (EN) has been associated with improved transplant outcomes, yet standardized early EN practices remain inconsistently adopted across centers.

methodsThis retrospective cohort study evaluated the adoption and clinical outcomes of a standardized Day +1 EN protocol in patients undergoing Allo-SCT. The protocol included feeding tube (FT) placement on Day +1 with EN initiated at 25 mL/h. Demographic and clinical data were extracted from electronic health records for patients treated after protocol adoption (post-protocol) and retrospective controls from one year prior (pre-protocol group). Outcomes included successful Day +1 EN initiation, gastrointestinal (GI) complications, FT removal reason, and occurrence and severity of lower GI and overall aGvHD by Day +100 (Modified Glucksberg Criteria). Group comparisons used Welch's

resultsThe final cohort included 108 patients (67 pre-protocol and 41 post-protocol). Successful Day +1 EN initiation occurred in 95.1% (n = 39) of patients post-protocol versus 4.5% (n = 3) pre-protocol (

conclusionsAdoption of a standardized Day +1 EN protocol in Allo-SCT patients was successfully implemented and well-tolerated without adverse FT-related events. The significant difference in lower GI GvHD occurrence in the post-protocol group warrants confirmation of Day+1 EN in patients receiving an Allo-SCT in a future randomized trial.

Indexed as

Enteral NutritionGraft vs Host DiseaseHematopoietic Stem Cell TransplantationStem Cell TransplantationAdultClinical ProtocolsFemaleGastrointestinal DiseasesHumansMaleMiddle AgedRetrospective StudiesTransplantation, HomologousTreatment OutcomeYoung Adultadultenteral nutritiongraft vs. host diseasenutritiontransplant

Identifiers

PMID42124060
PMCPMC13164932

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