Evidence map›Paper›PMID 42123902›Full record

ArticleMolecules (Basel, Switzerland)2026

Characterization of the Composition and Immunoregulatory Activity of Wheat Cell Culture-Derived Polysaccharides.

Alima Murtazina, Pol Rodríguez-Martínez, Dylan J Crawshaw, Carme Caelles, Anel Tarabayeva, Elmira Bitanova, Nadezhda Ibragimova, Polina Mikshina, Tatyana Gorshkova, Gordon J McDougall and 3 more

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alima MurtazinaDepartment of General Immunology, Faculty of Medicine, Asfendyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.
Pol Rodríguez-MartínezInstitute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain.
Dylan J CrawshawInstitute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain.
Carme CaellesInstitute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain.
Anel TarabayevaDepartment of General Immunology, Faculty of Medicine, Asfendyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.ORCID 0000-0002-2851-2396
Elmira BitanovaDepartment of General Immunology, Faculty of Medicine, Asfendyarov Kazakh National Medical University, Almaty 050012, Kazakhstan.ORCID 0000-0003-3976-9653
Nadezhda IbragimovaFRC Kazan Scientific Center, Kazan Institute of Biochemistry and Biophysics (KIBB), Russian Academy of Sciences, 420111 Kazan, Russia.
Polina MikshinaFRC Kazan Scientific Center, Kazan Institute of Biochemistry and Biophysics (KIBB), Russian Academy of Sciences, 420111 Kazan, Russia.
Tatyana GorshkovaFRC Kazan Scientific Center, Kazan Institute of Biochemistry and Biophysics (KIBB), Russian Academy of Sciences, 420111 Kazan, Russia.ORCID 0000-0003-0342-8195
Gordon J McDougallPlant Biochemistry and Food Quality Group, Environmental and Biochemical Sciences Department, The James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.ORCID 0000-0002-2285-0124
Houria BoulaizDepartment of Anatomy and Human Embryology, Faculty of Medicine, University of Granada, 18016 Granada, Spain.ORCID 0000-0003-4433-7556
Nazira BishimbayevaResearch Center "Bioscience Technologies", Almaty 050057, Kazakhstan.ORCID 0000-0002-4080-0761
Annabel F ValledorInstitute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain.ORCID 0000-0003-4232-2633

Funding

Agència de Gestió d'Ajuts Universitaris i de Recerca 2021SGR01433MICIU/AEI/10.13039/501100011033 PID2020-119875RB-I00Rural and Environment Science and Analytical Services to G.J.M.Universitat de Barcelona 2024TR102059WJ
6 · The paper itself

Abstract

Plant polysaccharides can exert immunomodulatory activities. In this study we provided chemical characterization of wheat cell culture-derived polysaccharides (WCCPS) and assessed their capacity to modulate inflammatory responses in mouse macrophages. The total sample (T-010) contained arabinogalactans, arabinans, glucans and xyloglucans. Fractionation by anion-exchange chromatography rendered a bound acidic fraction (B-010) and an unbound neutral fraction (UB-010). The B-010 fraction was enriched in arabinogalactans and arabinans, with some galactans, homogalacturonans, and arabinoxylans. The neutral UB-010 fraction was composed of glucans and xyloglucans. None of the WCCPS preparations triggered cytokine production on their own, but each potentiated different macrophage responses to bacterial lipopolysaccharide (LPS). The total WCCPS in T-010 increased LPS-induced tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 secretion, whereas the acidic arabinogalactan-rich fraction B-010 boosted IL-6 release and selectively upregulated nitric oxide synthase 2 (

Indexed as

Immunologic FactorsPolysaccharidesTriticumAnimalsCytokinesGalactansGlucansInterleukin-6LipopolysaccharidesMacrophagesMiceNitric Oxide Synthase Type IITumor Necrosis Factor-alphaXylansarabinogalactanCytokinesGalactansGlucansImmunologic FactorsInterleukin-6LipopolysaccharidesNitric Oxide Synthase Type IINos2 protein, mousePolysaccharidesTumor Necrosis Factor-alphaXylansxyloglucancytokineLPSmacrophagepolysaccharidewheat cell culture

Identifiers

PMID42123902
PMCPMC13165246

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.